The emerging role of obesity, diet and lipid metabolism in prostate cancer

Obesity is associated with an increased risk of a number of serious medical conditions, including cancer. As far as prostate cancer is concerned, obesity is associated with an increased risk of high-grade tumors, which is possibly related to lower androgen levels. Diet may also affect prostate cance...

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Bibliographic Details
Published in:Future oncology (London, England) England), 2017-02, Vol.13 (3), p.285-293
Main Authors: Ferro, Matteo, Terracciano, Daniela, Buonerba, Carlo, Lucarelli, Giuseppe, Bottero, Danilo, Perdonà, Sisto, Autorino, Riccardo, Serino, Alessandro, Cantiello, Francesco, Damiano, Rocco, Andras, Iulia, De Placido, Sabino, Di Lorenzo, Giuseppe, Battaglia, Michele, Jereczek-Fossa, Barbara A, Mirone, Vincenzo, De Cobelli, Ottavio
Format: Article
Language:English
Subjects:
Adipocytes - metabolism
Androgens
Breast cancer
Cardiovascular disease
Cell cycle
Cell Transformation, Neoplastic - metabolism
Diet
Fatty acids
Health risk assessment
Humans
Kinases
Lipid Metabolism
Male
Obesity
Obesity - complications
Obesity - metabolism
Prostate cancer
Prostatic Neoplasms - etiology
Prostatic Neoplasms - metabolism
Review
Tumors
urologic/prostate
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Summary:Obesity is associated with an increased risk of a number of serious medical conditions, including cancer. As far as prostate cancer is concerned, obesity is associated with an increased risk of high-grade tumors, which is possibly related to lower androgen levels. Diet may also affect prostate cancer risk since countries with a higher dietary fat intake also present higher prostate cancer mortality rates. Interestingly, prostate cancer is associated with a number of metabolic alterations that may provide valuable diagnostic and therapeutic targets. This review explores the available clinical as well as biological evidence supporting the relationship between obesity, diet, alteration in metabolic pathways and prostate cancer.
ISSN:1479-6694
1744-8301
DOI:10.2217/fon-2016-0217