Estimating and Interpreting Effects from Nonlinear Exposure-Response Curves in Occupational Cohorts Using Truncated Power Basis Expansions and Penalized Splines

Truncated power basis expansions and penalized spline methods are demonstrated for estimating nonlinear exposure-response relationships in the Cox proportional hazards model. R code is provided for fitting models to get point and interval estimates. The method is illustrated using a simulated data s...

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Bibliographic Details
Published in:Computational and mathematical methods in medicine 2017-01, Vol.2017 (2017), p.1-16
Main Authors: Malloy, Elizabeth J., Garg, Arun, Kapellusch, Jay
Format: Article
Language:English
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Summary:Truncated power basis expansions and penalized spline methods are demonstrated for estimating nonlinear exposure-response relationships in the Cox proportional hazards model. R code is provided for fitting models to get point and interval estimates. The method is illustrated using a simulated data set under a known exposure-response relationship and in a data application examining risk of carpal tunnel syndrome in an occupational cohort.
ISSN:1748-670X
1748-6718
DOI:10.1155/2017/7518035