Twelve‐year mortality in adults initiating antiretroviral therapy in South Africa

• Published in: Journal of the International AIDS Society 2017, Vol.20 (1), p.21902-n/a
• Main Authors: Cornell, Morna, Johnson, Leigh F., Wood, Robin, Tanser, Frank, Fox, Matthew P., Prozesky, Hans, Schomaker, Michael, Egger, Matthias, Davies, Mary‐Ann, Boulle, Andrew
• Format: Article
• Language: English
• Subjects: Acquired immune deficiency syndrome; Adolescent; Adult; Adults; Africa; Aged; Aged, 80 and over; AIDS; AIDS (Disease); AIDS/HIV; Analysis; Anti-HIV Agents - therapeutic use; antiretroviral; Antiretroviral agents; Antiretroviral drugs; Care and treatment; CD4 Lymphocyte Count; Clinical outcomes; Cohort analysis; Cohort Studies; Collaboration; Disease transmission; Drug therapy; Epidemiology; Female; Females; Gender; Gender differences; Global health; Health aspects; Highly active antiretroviral therapy; HIV; HIV Infections - drug therapy; HIV Infections - epidemiology; HIV Infections - immunology; HIV Infections - mortality; Human immunodeficiency virus; Humans; Life expectancy; long‐term; Male; Medical care quality; Medical tests; Middle Aged; Mortality; outcomes; Patient outcomes; Patients; Primary care; Public health; Public sector; Risk factors; South Africa; South Africa - epidemiology; Statistics; Survival Analysis; Systematic review; Trends; Viral Load; viral suppression; Young Adult; Young adults
• ISSN: 1758-2652; 1758-2652
• DOI: 10.7448/IAS.20.1.21902

Introduction: South Africa has the largest number of individuals living with HIV and the largest antiretroviral therapy (ART) programme worldwide. In September 2016, ART eligibility was extended to all 7.1 million HIV‐positive South Africans. To ensure that further expansion of services does not compromise quality of care, long‐term outcomes must be monitored. Few studies have reported long‐term mortality in resource‐constrained settings, where mortality ascertainment is challenging. Combining site records with data linked to the national vital registration system, sites in the International Epidemiology Databases to Evaluate AIDS Southern Africa collaboration can identify >95% of deaths in patients with civil identification numbers (IDs). This study used linked data to explore long‐term mortality and viral suppression among adults starting ART in South Africa. Methods: The study was a cohort analysis of routine data on adults with IDs starting ART 2004–2015 in five large ART cohorts. Mortality was estimated overall and by gender using the Kaplan‐Meier estimator and Cox's proportional hazards regression. Standardized mortality ratios (SMRs) were calculated by dividing observed numbers of deaths by numbers expected if patients had been HIV‐negative. Viral suppression in patients with viral loads (VLs) in their last year of follow‐up was the secondary outcome. Results: Among 72,812 adults followed for 350,376 person years (pyrs), the crude mortality rate was 3.08 (95% CI 3.02–3.14)/100 pyrs. Patients were predominantly female (67%) and the percentage of men initiating ART did not increase. Cumulative mortality 12 years after ART initiation was 23.9% (33.4% male and 19.4% female). Mortality peaked in patients enrolling in 2007–2009 and was higher in men than women at all durations. Observed mortality rates were higher than HIV‐negative mortality, decreasing with duration. By 48 months, observed mortality was close to that in the HIV‐negative population, and SMRs were similar for all baseline CD4 strata. Three‐quarters of patients had VLs in their last year, and 86% of these were virally suppressed. Conclusions: The South African ART programme has shown a remarkable ability to initiate and manage patients successfully over 12 years, despite rapid expansion. With further scale‐up, testing and initiating men on ART must be a national priority.