Bringing Lung Function Prediction Equations to Diverse Populations

In this issue of the Journal, LaVange and colleagues (pp. 993-1003) leveraged a large, diverse sample of Latinos enrolled in HCHS/SOL (Hispanic Community Health Study/Study of Latinos) to identify between-group heterogeneity and develop subgroupspecific spirometry reference equations (4). Given the...

Full description

Saved in:
Bibliographic Details
Published in:American journal of respiratory and critical care medicine 2017-10, Vol.196 (8), p.942-944
Main Author: Galanter, Joshua M
Format: Article
Language:English
Subjects:
African Americans
Genetics
Health risk assessment
Hispanic Americans
Humans
Laboratories
Lung
Mens health
Minority & ethnic groups
Reference Values
Respiratory Function Tests
Respiratory Physiological Phenomena
Society
Socioeconomic factors
Spirometry
Vital Capacity
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:In this issue of the Journal, LaVange and colleagues (pp. 993-1003) leveraged a large, diverse sample of Latinos enrolled in HCHS/SOL (Hispanic Community Health Study/Study of Latinos) to identify between-group heterogeneity and develop subgroupspecific spirometry reference equations (4). Given the higher prevalence of asthma and chronic obstructive pulmonary disease in these populations (12), the need for accurate reference equations is especially acute. Because HCHS/SOL did not recruit children, there remains a need for high-quality reference equations for Puerto Rican, Dominican, and other Latino children. Previous studies have shown that incorporating African ancestry into lung function prediction equations could improve estimates for normal lung function in healthy African Americans (16), and that subcontinental ancestry was correlated with lung function in Mexicans (15). Genetic diversity and association studies in US Hispanic/Latino populations: applications in the Hispanic Community Health Study/Study of Latinos.
ISSN:1073-449X
1535-4970
DOI:10.1164/rccm.201706-1181ED