Association between post-transplant red cell distribution width and prognosis of kidney transplant recipients

The role of elevated post-transplant red cell distribution width (RDW) as a predictive factor for graft loss remains unclear, although RDW was reported to be significantly associated with poor prognosis in various clinical fields. We performed a retrospective cohort study with 2,939 kidney transplan...

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Bibliographic Details
Published in:Scientific reports 2017-10, Vol.7 (1), p.13755-11, Article 13755
Main Authors: Park, Sehoon, Kim, Young Hoon, Kim, Yong Chul, Yu, Mi-Yeon, Lee, Jung Pyo, Han, Duck Jong, Kim, Yon Su, Park, Su-Kil
Format: Article
Language:English
Subjects:
692/4022/1585/104/1586
692/499
Adult
Anemia
Erythrocyte Indices
Erythrocytes - pathology
Female
Graft rejection
Graft Rejection - blood
Graft Rejection - etiology
Graft Rejection - mortality
Grafts
Hemoglobin
Humanities and Social Sciences
Humans
Kidney Diseases - mortality
Kidney Diseases - surgery
Kidney transplantation
Kidney Transplantation - adverse effects
Kidney Transplantation - mortality
Kidney transplants
Male
Middle Aged
multidisciplinary
Postoperative Complications - blood
Postoperative Complications - etiology
Postoperative Complications - mortality
Prognosis
Retrospective Studies
Risk Assessment
Science
Science (multidisciplinary)
Survival Rate
Transplant Recipients
Transplantation
Transplants & implants
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Summary:The role of elevated post-transplant red cell distribution width (RDW) as a predictive factor for graft loss remains unclear, although RDW was reported to be significantly associated with poor prognosis in various clinical fields. We performed a retrospective cohort study with 2,939 kidney transplant patients from two tertiary teaching hospitals in Korea. RDW level at transplantation and 3-months post-transplantation were collected. Those with RDW in the upper quartile range were considered to have increased RDW (>14.9%). Death-with-graft-function (DWGF), death-censored graft failure (DCGF), and composite graft loss were assessed as the study outcomes, using multivariable cox proportional hazard model. At the median follow-up duration of 6.6 (3.6–11.4) years, 336 patients experienced graft loss. There were 679 patients with elevated RDW at 3-months post-transplant. Elevated RDW was associated with composite graft loss (adjusted hazard ratio, 1.60, 95% confidence interval, 1.23–2.07, P 
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-017-13952-6