Coffee consumption is not associated with prevalent subclinical cardiovascular disease (CVD) or the risk of CVD events, in nonalcoholic fatty liver disease: results from the multi-ethnic study of atherosclerosis

Atherosclerosis and its clinical sequelae represent the leading cause of mortality among patients with nonalcoholic fatty liver disease (NAFLD). While epidemiologic data support the hepatoprotective benefits of coffee in NAFLD, whether coffee improves NAFLD-associated CVD risk is unknown. We examine...

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Bibliographic Details
Published in:Metabolism, clinical and experimental clinical and experimental, 2017-10, Vol.75, p.1-5
Main Authors: Simon, Tracey G., Trejo, Maria Esther Perez, Zeb, Irfan, Frazier-Wood, Alexis C., McClelland, Robyn L., Chung, Raymond T., Budoff, Matthew J.
Format: Article
Language:English
Subjects:
Aged
Atherosclerosis
Cardiovascular disease
Cardiovascular Diseases - etiology
Coffee
Coffee - adverse effects
Coronary atherosclerosis
Ethnicity
Fatty liver disease
Follow-Up Studies
Humans
Middle Aged
NAFLD
Non-alcoholic Fatty Liver Disease - complications
Regression Analysis
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Summary:Atherosclerosis and its clinical sequelae represent the leading cause of mortality among patients with nonalcoholic fatty liver disease (NAFLD). While epidemiologic data support the hepatoprotective benefits of coffee in NAFLD, whether coffee improves NAFLD-associated CVD risk is unknown. We examined 3710 ethnically-diverse participants from the Multi-Ethnic Study of Atherosclerosis (MESA) cohort, without history of known liver disease, and with available coffee data from a validated 120-item food frequency questionnaire. All participants underwent baseline non-contrast cardiac CT from which NAFLD was defined by liver:spleen ratio (L:S0. Major CVD events were defined by the first occurrence of myocardial infarction, cardiac arrest, angina, stroke, or CVD death. We used log-binomial regression to calculate the adjusted prevalence ratio (PR) for CAC>0 by coffee intake and NAFLD status, and events were compared between groups using frequency of events within adjusted Cox proportional hazard regression models. Seventeen percent (N=637) of participants met criteria for NAFLD. NAFLD participants were more likely to have elevated BMI (mean 31.1±5.5kg/m2 vs. 28.0±5.2kg/m2, p
ISSN:0026-0495
1532-8600
DOI:10.1016/j.metabol.2017.06.007