Predictors of Bowel Function in Long-term Rectal Cancer Survivors with Anastomosis

Background Bowel function in long-term rectal cancer survivors with anastomosis has not been characterized adequately. We hypothesized that bowel function is associated with patient, disease, and treatment characteristics. Methods The cohort study included Kaiser Permanente members who were long-ter...

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Bibliographic Details
Published in:Annals of surgical oncology 2017-11, Vol.24 (12), p.3596-3603
Main Authors: Alavi, Mubarika, Wendel, Christopher S., Krouse, Robert S., Temple, Larissa, Hornbrook, Mark C., Bulkley, Joanna E., McMullen, Carmit K., Grant, Marcia, Herrinton, Lisa J.
Format: Article
Language:English
Subjects:
Aged
Anastomosis
Anastomosis, Surgical - adverse effects
Cancer
Cancer surgery
Cancer Survivors
Cancer therapies
Colorectal Cancer
Cross-Sectional Studies
Decision making
Female
Follow-Up Studies
Humans
Intestine
Long Term Adverse Effects - etiology
Longitudinal Studies
Male
Medicine
Medicine & Public Health
Oncology
Ostomy
Ostomy - adverse effects
Postoperative Complications
Prognosis
Radiation therapy
Rectal Neoplasms - surgery
Rectum
Smoking
Surgery
Surgical Oncology
Surveys and Questionnaires
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Summary:Background Bowel function in long-term rectal cancer survivors with anastomosis has not been characterized adequately. We hypothesized that bowel function is associated with patient, disease, and treatment characteristics. Methods The cohort study included Kaiser Permanente members who were long-term (≥5 years) rectal cancer survivors with anastomosis. Bowel function was scored using the self-administered, 14-item Memorial Sloan-Kettering Cancer Center Bowel Function Index. Patient, cancer, and treatment variables were collected from the electronic medical chart. We used multiple regression to assess the relationship of patient- and treatment-related variables with the bowel function score. Results The study included 381 anastomosis patients surveyed an average 12 years after their rectal cancer surgeries. The total bowel function score averaged 53 (standard deviation, 9; range, 31–70, higher scores represent better function). Independent factors associated with worse total bowel function score included receipt of radiation therapy (yes vs. no: 5.3-unit decrement, p  6 cm: 3.2-unit decrement, p  
ISSN:1068-9265
1534-4681
DOI:10.1245/s10434-017-6017-x