Targeting inflammation to reduce cardiovascular disease risk: a realistic clinical prospect?

Data from basic science experiments is overwhelmingly supportive of the causal role of immune‐inflammatory response(s) at the core of atherosclerosis, and therefore, the theoretical potential to manipulate the inflammatory response to prevent cardiovascular events. However, extrapolation to humans r...

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Bibliographic Details
Published in:British journal of pharmacology 2017-11, Vol.174 (22), p.3898-3913
Main Authors: Welsh, Paul, Grassia, Gianluca, Botha, Shani, Sattar, Naveed, Maffia, Pasquale
Format: Article
Language:English
Subjects:
Animals
Anti-Inflammatory Agents - therapeutic use
Anticholesteremic Agents - therapeutic use
Antioxidants - therapeutic use
Arteriosclerosis
Atherosclerosis
Biological Products - therapeutic use
Cardiovascular disease
Cardiovascular diseases
Cardiovascular Diseases - immunology
Cardiovascular Diseases - metabolism
Cardiovascular Diseases - prevention & control
Cytokines - immunology
Health risk assessment
Humans
Inflammation
Inflammation - drug therapy
Inflammatory response
Phospholipases A2 - metabolism
Review
Risk
Themed Section: Review
Vitamins - therapeutic use
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Summary:Data from basic science experiments is overwhelmingly supportive of the causal role of immune‐inflammatory response(s) at the core of atherosclerosis, and therefore, the theoretical potential to manipulate the inflammatory response to prevent cardiovascular events. However, extrapolation to humans requires care and we still lack definitive evidence to show that interfering in immune‐inflammatory processes may safely lessen clinical atherosclerosis. In this review, we discuss key therapeutic targets in the treatment of vascular inflammation, placing basic research in a wider clinical perspective, as well as identifying outstanding questions. Linked Articles This article is part of a themed section on Targeting Inflammation to Reduce Cardiovascular Disease Risk. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v174.22/issuetoc and http://onlinelibrary.wiley.com/doi/10.1111/bcp.v82.4/issuetoc
ISSN:0007-1188
1476-5381
DOI:10.1111/bph.13818