GENE-08. PHARMACOLOGIC MODULATION OF MYC AND PDGFRA BY TARGETING TOPOISOMERASE II ON GLIOMAS

Topoisomerase II (TOP2B) A/B regulate transcription by inducing double-strand DNA breaks and enhancing chromatin accessibility in other contexts, but their role in gliomas has not been elucidated. We investigated the effect of TOP2A/B on epigenetic regulation in glioma cell lines and explored the ta...

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Published in:Neuro-oncology (Charlottesville, Va.) Va.), 2017-11, Vol.19 (suppl_6), p.vi94-vi94
Main Authors: Gonzalez-Buendia, Edgar, Feldstein, Eric, Zhao, Junfei, Mahajan, Aayushi, Realubit, Ronald, Karan, Charles, Rabadan, Raul, Sonabend, Adam M
Format: Article
Language:English
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Summary:Topoisomerase II (TOP2B) A/B regulate transcription by inducing double-strand DNA breaks and enhancing chromatin accessibility in other contexts, but their role in gliomas has not been elucidated. We investigated the effect of TOP2A/B on epigenetic regulation in glioma cell lines and explored the targeting of this process as a therapeutic strategy.
ISSN:1522-8517
1523-5866
DOI:10.1093/neuonc/nox168.383