Cell fate decisions: emerging roles for metabolic signals and cell morphology

Understanding how cell fate decisions are regulated is a fundamental goal of developmental and stem cell biology. Most studies on the control of cell fate decisions address the contributions of changes in transcriptional programming, epigenetic modifications, and biochemical differentiation cues. Ho...

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Bibliographic Details
Published in:EMBO reports 2017-12, Vol.18 (12), p.2105-2118
Main Authors: Tatapudy, Sumitra, Aloisio, Francesca, Barber, Diane, Nystul, Todd
Format: Article
Language:English
Subjects:
Biology
Cell Biology
Cell Differentiation - genetics
Cell fate
Cell morphology
Cues
Cytology
Decisions
EMBO11
EMBO39
EMBO44
Hydrogen-Ion Concentration
intracellular pH
Kinases
Metabolism
Morphology
pH effects
Reactive oxygen species
Reactive Oxygen Species - metabolism
Review
Signal Transduction - genetics
Signal Transduction - physiology
Signaling
Stem cells
Stem Cells - metabolism
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Summary:Understanding how cell fate decisions are regulated is a fundamental goal of developmental and stem cell biology. Most studies on the control of cell fate decisions address the contributions of changes in transcriptional programming, epigenetic modifications, and biochemical differentiation cues. However, recent studies have found that other aspects of cell biology also make important contributions to regulating cell fate decisions. These cues can have a permissive or instructive role and are integrated into the larger network of signaling, functioning both upstream and downstream of developmental signaling pathways. Here, we summarize recent insights into how cell fate decisions are influenced by four aspects of cell biology: metabolism, reactive oxygen species (ROS), intracellular pH (pHi), and cell morphology. For each topic, we discuss how these cell biological cues interact with each other and with protein‐based mechanisms for changing gene transcription. In addition, we highlight several questions that remain unanswered in these exciting and relatively new areas of the field. Graphical Abstract Cell fate decisions are mainly considered to be regulated via transcriptional programming, epigenetic modifications, and biochemical differentiation triggers. This review discusses how different cell biological cues acting upstream and downstream of developmental signaling pathways influence lineage determination.
ISSN:1469-221X
1469-3178
DOI:10.15252/embr.201744816