Is mitochondrial DNA quantitation in blastocyst trophectoderm cells predictive of developmental competence and outcome in clinical IVF?

Behind every successful IVF embryo transfer, there is a great game of chance. Methods seeking to tilt the balance and increase the likelihood of implantation have been proposed and implemented with varying results, including embryo morphology, FISH-PGS, comprehensive chromosomal screening (CCS), mor...

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Bibliographic Details
Published in:Journal of assisted reproduction and genetics 2017-12, Vol.34 (12), p.1581-1585
Main Authors: Viotti, Manuel, Victor, Andrea R., Zouves, Christo G., Barnes, Frank L.
Format: Article
Language:English
Subjects:
Copy number
Embryo transfer
Embryos
Endometrium
Gynecology
Human Genetics
Implantation
In vitro fertilization
Medicine
Medicine & Public Health
Mitochondrial DNA
Quantitation
Reproductive Medicine
Review
Trophectoderm
Viability
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Summary:Behind every successful IVF embryo transfer, there is a great game of chance. Methods seeking to tilt the balance and increase the likelihood of implantation have been proposed and implemented with varying results, including embryo morphology, FISH-PGS, comprehensive chromosomal screening (CCS), morphokinetics, endometrial receptivity testing. It has been suggested that mitochondrial DNA (mtDNA) copy number could serve as a biomarker for embryo viability, but this concept was recently challenged. The world of IVF is left with unanswered questions: Why are there discrepancies in the reports? Should mtDNA copy number be considered to rank embryos for transfer? And in a broader sense, how well must a technique be validated before its implementation in the IVF clinic? Here, we explore these questions attempting to piece together the published data and suggest future directions to help unravel the subject matter.
ISSN:1058-0468
1573-7330
DOI:10.1007/s10815-017-1072-6