Clinical trials using mesenchymal stem cells in liver diseases and inflammatory bowel diseases

Mesenchymal stem cell (MSC) therapies have been used in clinical trials in various fields. These cells are easily expanded, show low immunogenicity, can be acquired from medical waste, and have multiple functions, suggesting their potential applications in a variety of diseases, including liver dise...

Full description

Saved in:
Bibliographic Details
Published in:Inflammation and Regeneration 2017-07, Vol.37 (1), p.16-16
Main Authors: Tsuchiya, Atsunori, Kojima, Yuichi, Ikarashi, Shunzo, Seino, Satoshi, Watanabe, Yusuke, Kawata, Yuzo, Terai, Shuji
Format: Article
Language:English
Subjects:
Alcohol
Bone marrow
Caregivers
Cartilage
Cell therapy
Clinical trials
Cytokines
Inflammatory bowel disease
Liver disease
Liver diseases
Mesenchymal stem cell
Review
Stem cells
Umbilical cord
Veins & arteries
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Mesenchymal stem cell (MSC) therapies have been used in clinical trials in various fields. These cells are easily expanded, show low immunogenicity, can be acquired from medical waste, and have multiple functions, suggesting their potential applications in a variety of diseases, including liver disease and inflammatory bowel disease. MSCs help prepare the microenvironment, in response to inflammatory cytokines, by producing immunoregulatory factors that modulate the progression of inflammation by affecting dendritic cells, B cells, T cells, and macrophages. MSCs also produce a large amount of cytokines, chemokines, and growth factors, including exosomes that stimulate angiogenesis, prevent apoptosis, block oxidation reactions, promote remodeling of the extracellular matrix, and induce differentiation of tissue stem cells. According to ClinicalTrials.gov, more than 680 clinical trials using MSCs are registered for cell therapy of many fields including liver diseases (more than 40 trials) and inflammatory bowel diseases (more than 20 trials). In this report, we introduce background and clinical studies of MSCs in liver disease and inflammatory bowel diseases.
ISSN:1880-9693
1880-8190
DOI:10.1186/s41232-017-0045-6