Roles of toll-like receptors: From inflammation to lung cancer progression

• Published in: Biomedical reports 2018-02, Vol.8 (2), p.126-132
• Main Authors: Gu, Jinjing, Liu, Yi, Xie, Bin, Ye, Pingping, Huang, Jiefan, Lu, Zhe
• Format: Article
• Language: English
• Subjects: Angiogenesis; Apoptosis; Cancer; Cancer therapies; Chemotherapy; Cytokines; Development and progression; DNA methylation; Epigenetics; Gene expression; Immune response; Immune system; Infections; Inflammation; Innate immunity; Kinases; Lung cancer; Medical prognosis; Metastasis; Mortality; Proteins; Receptors; Respiratory system agents; Review; Signal transduction; Signaling; Stem cell transplantation; Stem cells; Toll-like receptors; Tuberculosis; Tumor cells; Tumor necrosis factor-TNF; Tumorigenesis
• ISSN: 2049-9434; 2049-9442
• DOI: 10.3892/br.2017.1034

Lung cancer is among the most common malignant tumors worldwide, and is characterized by a low survival rate compared with other cancers. Toll-like receptors (TLRs) are highly conserved in evolution and widely expressed on immune cells, where they serve an important role in the innate immune system by evoking inflammatory responses. Evasion of immune destruction is an important hallmark in the development of cancer. There is an established association between chronic inflammation and cancer, with TLRs serving important roles in the immune response against tumor cells. Recently, TLRs have been identified on tumor cells, where their activation may orchestrate the downstream signaling pathways that serve crucial functions in tumorigenesis and tumor progression. The present review summarizes the roles of TLRs as sensors on lung cancer cells that regulate lung cancer progression with regard to cell growth and invasion, angiogenesis and cancer stem cell behavior. This aimed to provide theoretical support for the development of therapies that target TLR signaling pathways for the treatment of lung cancer.