The effect of frailty on HAI response to influenza vaccine among community-dwelling adults ≥ 50 years of age

The immune response to vaccine antigens is less robust in older adults because of changes in the aging immune system. Frailty, the multi-dimensional syndrome marked by losses in function and physiological reserve, is increasingly prevalent with advancing age. Frailty accelerates this immunosenescenc...

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Bibliographic Details
Published in:Human vaccines & immunotherapeutics 2018-02, Vol.14 (2), p.361-367
Main Authors: Moehling, Krissy K., Nowalk, Mary Patricia, Lin, Chyongchiou Jeng, Bertolet, Marnie, Ross, Ted M., Carter, Chalise E., Susick, Michael, Saul, Sean G., Kaynar, A. Murat, Bromberger, Joyce T., Zimmerman, Richard K.
Format: Article
Language:English
Subjects:
Aged
Aging
Antibodies, Viral - immunology
Female
Frail Elderly
Frailty
HAI titers
Humans
immunogenicity
Independent Living
influenza
Influenza A Virus, H1N1 Subtype
Influenza A Virus, H3N2 Subtype
Influenza B virus
Influenza Vaccines - immunology
Influenza, Human - prevention & control
Male
Middle Aged
Research Paper
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Summary:The immune response to vaccine antigens is less robust in older adults because of changes in the aging immune system. Frailty, the multi-dimensional syndrome marked by losses in function and physiological reserve, is increasingly prevalent with advancing age. Frailty accelerates this immunosenescence but the consequence of frailty on immune response specific to influenza vaccine among older adults, is mixed. An observational, prospective study of 114 adults was conducted in the fall of 2013 to assess the association of physical frailty with immune response to standard dose influenza vaccine in community-dwelling adults ≥ 50 years of age. Participants were stratified by age (
ISSN:2164-5515
2164-554X
DOI:10.1080/21645515.2017.1405883