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Association of obstructive sleep apnea with hypertension: A systematic review and meta-analysis
Obstructive sleep apnea (OSA) is a sleep disorder characterized as complete or partial upper airflow cessation during sleep. Although it has been widely accepted that OSA is a risk factor for the development of hypertension, the studies focusing on this topic revealed inconsistent results. We aimed...
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| Published in: | Journal of global health 2018-06, Vol.8 (1), p.010405-010405 |
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| creator | Hou, Haifeng Zhao, Yange Yu, Wenqing Dong, Hualei Xue, Xiaotong Ding, Jian Xing, Weijia Wang, Wei |
| description | Obstructive sleep apnea (OSA) is a sleep disorder characterized as complete or partial upper airflow cessation during sleep. Although it has been widely accepted that OSA is a risk factor for the development of hypertension, the studies focusing on this topic revealed inconsistent results. We aimed to clarify the association between OSA and hypertension, including essential and medication-resistant hypertension.
The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) was followed. PubMed and Embase databases were used for searching the relevant studies published up to December 31, 2016. A quantitative approach of meta-analysis was performed to estimate the pooled odds ratio (OR) and 95% confidence interval (CI).
Twenty-six studies with 51 623 participants (28 314 men, 23 309 women; mean age 51.8 years) met inclusion criteria and were included in this study. Among them, six studies showed a significant association between OSA and resistant hypertension (pooled OR = 2.842, 95% CI = 1.703-3.980,
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| doi_str_mv | 10.7189/jogh.08.010405 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5825975</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2020285605</sourcerecordid><originalsourceid>FETCH-LOGICAL-c418t-b36fc54ffb43d705741c5d279ca6ea4c0e0fdcc39baa6d043a83dc4df912374f3</originalsourceid><addsrcrecordid>eNpdkc2LFDEQxYMo7rLu1aMEvHjpMZ2kO2kPwrD4BQte9BzS6cpOhu5Om0rPMv-9GWYd1OSQgvzqUfUeIa9rtlG17t7v48Nuw_SG1Uyy5hm55kyqine6fX6plb4it4h7Vo6qBdftS3LFO9mphvFrYraI0QWbQ5xp9DT2mNPqcjgAxRFgoXaZwdLHkHd0d1wgZZixwB_oluIRM0yl19EEhwCP1M4DnSDbys52PGLAV-SFtyPC7dN7Q35-_vTj7mt1__3Lt7vtfeVkrXPVi9a7RnrfSzEo1ihZu2bgqnO2BSsdA-YH50TXW9sOTAqrxeDk4LuaCyW9uCEfz7rL2k8wOJhzsqNZUphsOppog_n3Zw478xAPptG8KV4UgXdPAin-WgGzmQI6GEc7Q1zR8GKyaDvJdUHf_ofu45rKwieqXN207CS4OVMuRcQE_jJMzcwpPnOKzzBtzvGVhjd_r3DB_4QlfgOaQJjq</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2020285605</pqid></control><display><type>article</type><title>Association of obstructive sleep apnea with hypertension: A systematic review and meta-analysis</title><source>Publicly Available Content Database (Proquest) (PQ_SDU_P3)</source><source>PubMed Central</source><creator>Hou, Haifeng ; Zhao, Yange ; Yu, Wenqing ; Dong, Hualei ; Xue, Xiaotong ; Ding, Jian ; Xing, Weijia ; Wang, Wei</creator><creatorcontrib>Hou, Haifeng ; Zhao, Yange ; Yu, Wenqing ; Dong, Hualei ; Xue, Xiaotong ; Ding, Jian ; Xing, Weijia ; Wang, Wei</creatorcontrib><description>Obstructive sleep apnea (OSA) is a sleep disorder characterized as complete or partial upper airflow cessation during sleep. Although it has been widely accepted that OSA is a risk factor for the development of hypertension, the studies focusing on this topic revealed inconsistent results. We aimed to clarify the association between OSA and hypertension, including essential and medication-resistant hypertension.
The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) was followed. PubMed and Embase databases were used for searching the relevant studies published up to December 31, 2016. A quantitative approach of meta-analysis was performed to estimate the pooled odds ratio (OR) and 95% confidence interval (CI).
Twenty-six studies with 51 623 participants (28 314 men, 23 309 women; mean age 51.8 years) met inclusion criteria and were included in this study. Among them, six studies showed a significant association between OSA and resistant hypertension (pooled OR = 2.842, 95% CI = 1.703-3.980,
< 0.05). Meanwhile, the combination of 20 original studies on the association of OSA with essential hypertension also presented significant results with the pooled ORs of 1.184 (95% CI = 1.093-1.274,
< 0.05) for mild OSA, 1.316 (95% CI = 1.197-1.433,
< 0.05) for moderate OSA and 1.561 (95% CI = 1.287-1.835,
< 0.05) for severe OSA.
Our findings indicated that OSA is related to an increased risk of resistant hypertension. Mild, moderate and severe OSA are associated essential hypertension, as well a dose-response manner relationship is manifested. The associations are relatively stronger among Caucasians and male OSA patients.</description><identifier>ISSN: 2047-2978</identifier><identifier>EISSN: 2047-2986</identifier><identifier>DOI: 10.7189/jogh.08.010405</identifier><identifier>PMID: 29497502</identifier><language>eng</language><publisher>Scotland: Edinburgh University Global Health Society</publisher><subject>Age ; Bias ; Body mass index ; Ethnicity ; Global health ; Humans ; Hypertension ; Hypertension - epidemiology ; Meta-analysis ; Risk Factors ; Sleep apnea ; Sleep Apnea, Obstructive - epidemiology ; Statistical analysis ; Studies ; Systematic review</subject><ispartof>Journal of global health, 2018-06, Vol.8 (1), p.010405-010405</ispartof><rights>Copyright © 2018 by the Journal of Global Health. All rights reserved. This work is licensed under the Creative Commons Attribution License ( https://creativecommons.org/licenses/by/3.0/ ) (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Copyright © 2018 by the Journal of Global Health. All rights reserved. 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c418t-b36fc54ffb43d705741c5d279ca6ea4c0e0fdcc39baa6d043a83dc4df912374f3</citedby><cites>FETCH-LOGICAL-c418t-b36fc54ffb43d705741c5d279ca6ea4c0e0fdcc39baa6d043a83dc4df912374f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2020285605/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2020285605?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,25732,27903,27904,36991,36992,44569,53770,53772,74873</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29497502$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hou, Haifeng</creatorcontrib><creatorcontrib>Zhao, Yange</creatorcontrib><creatorcontrib>Yu, Wenqing</creatorcontrib><creatorcontrib>Dong, Hualei</creatorcontrib><creatorcontrib>Xue, Xiaotong</creatorcontrib><creatorcontrib>Ding, Jian</creatorcontrib><creatorcontrib>Xing, Weijia</creatorcontrib><creatorcontrib>Wang, Wei</creatorcontrib><title>Association of obstructive sleep apnea with hypertension: A systematic review and meta-analysis</title><title>Journal of global health</title><addtitle>J Glob Health</addtitle><description>Obstructive sleep apnea (OSA) is a sleep disorder characterized as complete or partial upper airflow cessation during sleep. Although it has been widely accepted that OSA is a risk factor for the development of hypertension, the studies focusing on this topic revealed inconsistent results. We aimed to clarify the association between OSA and hypertension, including essential and medication-resistant hypertension.
The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) was followed. PubMed and Embase databases were used for searching the relevant studies published up to December 31, 2016. A quantitative approach of meta-analysis was performed to estimate the pooled odds ratio (OR) and 95% confidence interval (CI).
Twenty-six studies with 51 623 participants (28 314 men, 23 309 women; mean age 51.8 years) met inclusion criteria and were included in this study. Among them, six studies showed a significant association between OSA and resistant hypertension (pooled OR = 2.842, 95% CI = 1.703-3.980,
< 0.05). Meanwhile, the combination of 20 original studies on the association of OSA with essential hypertension also presented significant results with the pooled ORs of 1.184 (95% CI = 1.093-1.274,
< 0.05) for mild OSA, 1.316 (95% CI = 1.197-1.433,
< 0.05) for moderate OSA and 1.561 (95% CI = 1.287-1.835,
< 0.05) for severe OSA.
Our findings indicated that OSA is related to an increased risk of resistant hypertension. Mild, moderate and severe OSA are associated essential hypertension, as well a dose-response manner relationship is manifested. The associations are relatively stronger among Caucasians and male OSA patients.</description><subject>Age</subject><subject>Bias</subject><subject>Body mass index</subject><subject>Ethnicity</subject><subject>Global health</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Hypertension - epidemiology</subject><subject>Meta-analysis</subject><subject>Risk Factors</subject><subject>Sleep apnea</subject><subject>Sleep Apnea, Obstructive - epidemiology</subject><subject>Statistical analysis</subject><subject>Studies</subject><subject>Systematic review</subject><issn>2047-2978</issn><issn>2047-2986</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><recordid>eNpdkc2LFDEQxYMo7rLu1aMEvHjpMZ2kO2kPwrD4BQte9BzS6cpOhu5Om0rPMv-9GWYd1OSQgvzqUfUeIa9rtlG17t7v48Nuw_SG1Uyy5hm55kyqine6fX6plb4it4h7Vo6qBdftS3LFO9mphvFrYraI0QWbQ5xp9DT2mNPqcjgAxRFgoXaZwdLHkHd0d1wgZZixwB_oluIRM0yl19EEhwCP1M4DnSDbys52PGLAV-SFtyPC7dN7Q35-_vTj7mt1__3Lt7vtfeVkrXPVi9a7RnrfSzEo1ihZu2bgqnO2BSsdA-YH50TXW9sOTAqrxeDk4LuaCyW9uCEfz7rL2k8wOJhzsqNZUphsOppog_n3Zw478xAPptG8KV4UgXdPAin-WgGzmQI6GEc7Q1zR8GKyaDvJdUHf_ofu45rKwieqXN207CS4OVMuRcQE_jJMzcwpPnOKzzBtzvGVhjd_r3DB_4QlfgOaQJjq</recordid><startdate>20180601</startdate><enddate>20180601</enddate><creator>Hou, Haifeng</creator><creator>Zhao, Yange</creator><creator>Yu, Wenqing</creator><creator>Dong, Hualei</creator><creator>Xue, Xiaotong</creator><creator>Ding, Jian</creator><creator>Xing, Weijia</creator><creator>Wang, Wei</creator><general>Edinburgh University Global Health Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>EHMNL</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20180601</creationdate><title>Association of obstructive sleep apnea with hypertension: A systematic review and meta-analysis</title><author>Hou, Haifeng ; 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Although it has been widely accepted that OSA is a risk factor for the development of hypertension, the studies focusing on this topic revealed inconsistent results. We aimed to clarify the association between OSA and hypertension, including essential and medication-resistant hypertension.
The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) was followed. PubMed and Embase databases were used for searching the relevant studies published up to December 31, 2016. A quantitative approach of meta-analysis was performed to estimate the pooled odds ratio (OR) and 95% confidence interval (CI).
Twenty-six studies with 51 623 participants (28 314 men, 23 309 women; mean age 51.8 years) met inclusion criteria and were included in this study. Among them, six studies showed a significant association between OSA and resistant hypertension (pooled OR = 2.842, 95% CI = 1.703-3.980,
< 0.05). Meanwhile, the combination of 20 original studies on the association of OSA with essential hypertension also presented significant results with the pooled ORs of 1.184 (95% CI = 1.093-1.274,
< 0.05) for mild OSA, 1.316 (95% CI = 1.197-1.433,
< 0.05) for moderate OSA and 1.561 (95% CI = 1.287-1.835,
< 0.05) for severe OSA.
Our findings indicated that OSA is related to an increased risk of resistant hypertension. Mild, moderate and severe OSA are associated essential hypertension, as well a dose-response manner relationship is manifested. The associations are relatively stronger among Caucasians and male OSA patients.</abstract><cop>Scotland</cop><pub>Edinburgh University Global Health Society</pub><pmid>29497502</pmid><doi>10.7189/jogh.08.010405</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Age Bias Body mass index Ethnicity Global health Humans Hypertension Hypertension - epidemiology Meta-analysis Risk Factors Sleep apnea Sleep Apnea, Obstructive - epidemiology Statistical analysis Studies Systematic review |
| title | Association of obstructive sleep apnea with hypertension: A systematic review and meta-analysis |
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