Recurrent urolithiasis following parathyroidectomy for primary hyperparathyroidism

• Published in: Annals of the Royal College of Surgeons of England 2013-10, Vol.95 (7), p.523-528
• Main Authors: Rowlands, C, Zyada, A, Zouwail, S, Joshi, H, Stechman, M J, Scott-Coombes, D M
• Format: Article
• Language: English
• Subjects: Adolescent; Adult; Aged; Aged, 80 and over; Analysis of Variance; Biochemistry; Biomarkers - metabolism; Family medical history; Female; Haplotypes; Homeostasis; Humans; Hyperparathyroidism, Primary - surgery; Kidney Calculi - prevention & control; Kidney stones; Male; Middle Aged; Parathyroidectomy; Patients; Prospective Studies; Recurrence; Surgeons; Surgery; Tumors; Urine; Urology; Young Adult
• ISSN: 0035-8843; 1478-7083
• DOI: 10.1308/003588413X13629960048712

The effect of parathyroidectomy on the incidence of recurrent stone formation is uncertain. We aimed to compare the biochemistry and recurrence rate of urolithiasis in patients with primary hyperparathyroidism (pHPT) and stone formation (SF) and non-stone formation (NSF) with idiopathic stone formers (ISF). Patients with pHPT and SF (Group 1) were identified from a prospective database. pHPT patients and NSF (Group 2) and ISFs (Group 3) were randomly selected from respective databases to form three equal groups. Preoperative and postoperative biochemical data were analysed and recurrent urolithiasis diagnosed if present on follow-up radiology. Out-of-area patients were asked about recurrence via telephone. From July 2002 to October 2011, 640 patients had parathyroidectomy for pHPT. Of these, 66 (10.3%) had a history of renal colic; one was lost to follow-up. Patient demographics were similar across all three groups. Three months post-parathyroidectomy, Groups 1 and 2 had significantly reduced serum calcium concentrations (p