Acupressure bands do not improve chemotherapy‐induced nausea control in pediatric patients receiving highly emetogenic chemotherapy: A single‐blinded, randomized controlled trial

BACKGROUND Chemotherapy‐induced nausea and vomiting remain common, distressing side effects of chemotherapy. It has been reported that acupressure prevents chemotherapy‐induced nausea in adults, but it has not been well studied in children. METHODS In this multicenter, prospective, randomized, singl...

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Bibliographic Details
Published in:Cancer 2018-03, Vol.124 (6), p.1188-1196
Main Authors: Dupuis, L. Lee, Kelly, Kara M., Krischer, Jeffrey P., Langevin, Anne‐Marie, Tamura, Roy N., Xu, Ping, Chen, Lu, Kolb, E. Anders, Ullrich, Nicole J., Sahler, Olle Jane Z., Hendershot, Eleanor, Stratton, Ann, Sung, Lillian, McLean, Thomas W.
Format: Article
Language:English
Subjects:
Acupressure
Adults
Cancer
Chemotherapy
Children
Confidence limits
Nausea
Oncology
Patients
Pediatrics
Randomization
Side effects
supportive care
Vomiting
Wrist
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Summary:BACKGROUND Chemotherapy‐induced nausea and vomiting remain common, distressing side effects of chemotherapy. It has been reported that acupressure prevents chemotherapy‐induced nausea in adults, but it has not been well studied in children. METHODS In this multicenter, prospective, randomized, single‐blind, sham‐controlled trial, the authors compared acute‐phase nausea severity in patients ages 4 to 18 years who were receiving highly emetic chemotherapy using standard antiemetic agents combined with acupressure wrist bands, the most common type of acupressure, versus sham bands. Patients wore acupressure or sham bands continuously on each day of chemotherapy and for up to 7 days afterward. Chemotherapy‐induced nausea severity in the delayed phase and chemotherapy‐induced vomiting control in the acute and delayed phases also were compared. RESULTS Of the 187 patients randomized, 165 contributed nausea severity assessments during the acute phase. Acupressure bands did not reduce the severity of chemotherapy‐induced nausea in the acute phase (odds ratio [OR], 1.33; 95% confidence limits, 0.89‐2.00, in which an OR
ISSN:0008-543X
1097-0142
DOI:10.1002/cncr.31198