Methodological challenges in studying the causal determinants of child growth

Previous studies of early life influences on later growth in childhood have varied in their analytical approaches, particularly with respect to 'adjustment' for differences in size at the beginning of the growth period examined. We compared three commonly used statistical models to assess...

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Bibliographic Details
Published in:International journal of epidemiology 2016-12, Vol.45 (6), p.2030-2037
Main Authors: Kramer, Michael S, Zhang, Xun, Bin Aris, Izzuddin, Dahhou, Mourad, Naimi, Ashley, Yang, Seungmi, Martin, Richard M, Oken, Emily, Platt, Robert W
Format: Article
Language:English
Subjects:
Methodological Insights
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Summary:Previous studies of early life influences on later growth in childhood have varied in their analytical approaches, particularly with respect to 'adjustment' for differences in size at the beginning of the growth period examined. We compared three commonly used statistical models to assess the effect of maternal body mass index (BMI) on growth between 6.5 and 11.5 years in a large cohort of Belarusian children, as follows: (Model 1) analysis of the difference in anthropometric measurements between the two ages; (Model 2) analysis of the measurement at 11.5 years after adjustment for the same measurement at 6.5 years; and (Model 3) analysis of the difference in measurements after adjustment for the measurement at 6.5 years (mathematically identical to Model 2). Among PROBIT children of obese mothers (BMI ≥ 30 kg/m 2 ) vs those of mothers with normal BMI (18.5 to 
ISSN:0300-5771
1464-3685
DOI:10.1093/ije/dyw090