Mild Cognitive Impairment in Parkinson’s Disease—What Is It?

Purpose of Review Mild cognitive impairment is a common feature of Parkinson’s disease, even at the earliest disease stages, but there is variation in the nature and severity of cognitive involvement and in the risk of conversion to Parkinson’s disease dementia. This review aims to summarise current...

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Bibliographic Details
Published in:Current neurology and neuroscience reports 2018-04, Vol.18 (4), p.17-11, Article 17
Main Authors: Weil, Rimona S., Costantini, Alyssa A., Schrag, Anette E.
Format: Article
Language:English
Subjects:
Biomarkers
Cognitive ability
Cognitive Dysfunction - etiology
Cognitive Dysfunction - pathology
Dementia
Dementia - etiology
Dementia - physiopathology
Dementia disorders
Disease Progression
Humans
Medicine
Medicine & Public Health
Movement disorders
Movement Disorders (S Fox
Movement Disorders (S Fox, Section Editor)
Neurodegenerative diseases
Neurology
Neuropsychological Tests
Neurosciences
Parkinson Disease - complications
Parkinson Disease - physiopathology
Parkinson's disease
Phenotypes
Section Editor
Topical Collection on Movement Disorders
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Summary:Purpose of Review Mild cognitive impairment is a common feature of Parkinson’s disease, even at the earliest disease stages, but there is variation in the nature and severity of cognitive involvement and in the risk of conversion to Parkinson’s disease dementia. This review aims to summarise current understanding of mild cognitive impairment in Parkinson’s disease. We consider the presentation, rate of conversion to dementia, underlying pathophysiology and potential biomarkers of mild cognitive impairment in Parkinson’s disease. Finally, we discuss challenges and controversies of mild cognitive impairment in Parkinson’s disease. Recent Findings Large-scale longitudinal studies have shown that cognitive involvement is important and common in Parkinson’s disease and can present early in the disease course. Recent criteria for mild cognitive impairment in Parkinson’s provide the basis for further study of cognitive decline and for the progression of different cognitive phenotypes and risk of conversion to dementia. Summary Improved understanding of the underlying pathology and progression of cognitive change are likely to lead to opportunities for early intervention for this important aspect of Parkinson’s disease.
ISSN:1528-4042
1534-6293
DOI:10.1007/s11910-018-0823-9