Is treatment of fatty liver effective on reducing carotid intima media thickness; a cohort study

• Published in: Gastroenterology and hepatology from bed to bench 2018-01, Vol.11 (1), p.9-14
• Main Authors: Ghaffarifar, Saeideh, Khoshbaten, Manouchehr, Dordaei, Fattaneh, Zareh Nahandi, Maryam, Javad-Rashid, Reza, Shahnazi, Tahereh
• Format: Article
• Language: English
• Subjects: Original
• ISSN: 2008-2258; 2008-4234
• DOI: 10.22037/ghfbb.v0i0.1112

This study was intended to explore the effect of various drugs used to treat fatty liver on intimal-media thickness in patients with NAFLD. Nonalcoholic fatty liver disease (NAFLD) is an indicator of a broad spectrum of pathologic disorders, which is characterized with macro vesicular steatosis in the absent of alcohol use. It has a wide range of laboratory, clinical and pathological presentations such as simple steatosis to the diseases like non-alcoholic steatohepatitis, fibrosis, and cirrhosis and hepatocellular cancer. In this cross - sectional study, as a part of a 10-year cohort study (from 2007-2017) at Tabriz University of Medical Sciences, a group of 100 patients with NAFLD were studied. They were examined by color doppler sonography of the carotid arteries to detect any carotid intima- media thickness, before and one year after treatment with various drugs. The effect of treatment on right and left carotid intima- media thickness (IMT) was examined by using SPSS. V21. Over all, 36 (36%) patients were male and 64 (64%) were female. The mean age of the patients was a 43.5±10.3 year, ranging from 16 to 64. The decrease in patients' intima- media thickness in both right and left carotids was statistically significant (P