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Migraine and invasive epithelial ovarian cancer risk in the Nurses’ Health Study II and the Women's Health Study
Migraine is a common primary headache disorder, which predominantly impacts women. Recently, migraine has been hypothesized to be associated with hormonally related cancers; however, the potential association between migraine and ovarian cancer has not been studied. Therefore, we evaluated the assoc...
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| Published in: | International journal of cancer 2018-02, Vol.142 (3), p.534-539 |
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| container_end_page | 539 |
| container_issue | 3 |
| container_start_page | 534 |
| container_title | International journal of cancer |
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| creator | Rice, Megan S. Rist, Pamela M. Winter, Anke C. Kurth, Tobias Tworoger, Shelley S. |
| description | Migraine is a common primary headache disorder, which predominantly impacts women. Recently, migraine has been hypothesized to be associated with hormonally related cancers; however, the potential association between migraine and ovarian cancer has not been studied. Therefore, we evaluated the association between migraine and invasive epithelial ovarian cancer risk in two prospective cohorts, the Nurses’ Health Study II (NHSII) and the Women's Health Study (WHS). Our prospective analysis included 113,124 NHSII participants aged 25–42 at study baseline as well as 33,490 participants in the WHS who were 45 years or older at study entry. We used Cox proportional hazards models to estimate the hazard ratios (HR) and 95% confidence intervals (CIs) for the association between migraine and ovarian cancer risk in each cohort. In secondary analyses, we stratified by age and menopausal status. After adjusting for potential covariates, there was no statistically significant association between migraine and ovarian cancer risk in either the NHSII (HR = 1.29, 95%CI: 0.96, 1.74) or the WHS (HR = 0.60, 95%CI: 0.34, 1.06). In stratified analysis in the NHSII, there was a statistically significant positive association between migraine and ovarian cancer risk among women |
| doi_str_mv | 10.1002/ijc.31062 |
| format | article |
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What's new?
Migraine is more common in women than men, giving rise to the idea that hormones, particularly changing estrogen levels, trigger the condition. Recent studies further suggest that migraine may be associated with hormonally related cancers. Here, in two prospective cohorts, the Nurses’ Health Study II (NHSII), involving women ages 25–42 at baseline, and the Women's Health Study, with women 45 years or older, migraine was assessed for associations specifically with ovarian cancer. Overall, no statistically significant relationship was detected. Stratified analyses in the NHSII cohort revealed a positive association between migraine and ovarian cancer risk in women under age 45.</description><identifier>ISSN: 0020-7136</identifier><identifier>EISSN: 1097-0215</identifier><identifier>DOI: 10.1002/ijc.31062</identifier><identifier>PMID: 28929486</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>Age ; Cancer ; Carcinoma, Ovarian Epithelial ; Cohort Studies ; Estrogens ; Female ; Headache ; Health risk assessment ; Health risks ; Humans ; Invasiveness ; Medical personnel ; Medical research ; Middle Aged ; Migraine ; Migraine Disorders - epidemiology ; Neoplasms, Glandular and Epithelial - epidemiology ; Nurses ; Nurses - statistics & numerical data ; Ovarian cancer ; Ovarian carcinoma ; Ovarian Neoplasms - epidemiology ; Prospective Studies ; Risk ; Statistical analysis ; Statistical models ; Surveys and Questionnaires ; United States - epidemiology ; Women's Health ; Womens health</subject><ispartof>International journal of cancer, 2018-02, Vol.142 (3), p.534-539</ispartof><rights>2017 UICC</rights><rights>2017 UICC.</rights><rights>2018 UICC</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4432-54f6b192ace3d58342999529f92e6d6bd872dd1baefd689cab91d22abe0b24cb3</citedby><cites>FETCH-LOGICAL-c4432-54f6b192ace3d58342999529f92e6d6bd872dd1baefd689cab91d22abe0b24cb3</cites><orcidid>0000-0002-8900-4889</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28929486$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rice, Megan S.</creatorcontrib><creatorcontrib>Rist, Pamela M.</creatorcontrib><creatorcontrib>Winter, Anke C.</creatorcontrib><creatorcontrib>Kurth, Tobias</creatorcontrib><creatorcontrib>Tworoger, Shelley S.</creatorcontrib><title>Migraine and invasive epithelial ovarian cancer risk in the Nurses’ Health Study II and the Women's Health Study</title><title>International journal of cancer</title><addtitle>Int J Cancer</addtitle><description>Migraine is a common primary headache disorder, which predominantly impacts women. Recently, migraine has been hypothesized to be associated with hormonally related cancers; however, the potential association between migraine and ovarian cancer has not been studied. Therefore, we evaluated the association between migraine and invasive epithelial ovarian cancer risk in two prospective cohorts, the Nurses’ Health Study II (NHSII) and the Women's Health Study (WHS). Our prospective analysis included 113,124 NHSII participants aged 25–42 at study baseline as well as 33,490 participants in the WHS who were 45 years or older at study entry. We used Cox proportional hazards models to estimate the hazard ratios (HR) and 95% confidence intervals (CIs) for the association between migraine and ovarian cancer risk in each cohort. In secondary analyses, we stratified by age and menopausal status. After adjusting for potential covariates, there was no statistically significant association between migraine and ovarian cancer risk in either the NHSII (HR = 1.29, 95%CI: 0.96, 1.74) or the WHS (HR = 0.60, 95%CI: 0.34, 1.06). In stratified analysis in the NHSII, there was a statistically significant positive association between migraine and ovarian cancer risk among women <45 years of age (HR = 1.76, 95%CI: 1.01, 3.07). We did not observe a clear association between migraine and ovarian cancer risk in two large prospective cohort studies.
What's new?
Migraine is more common in women than men, giving rise to the idea that hormones, particularly changing estrogen levels, trigger the condition. Recent studies further suggest that migraine may be associated with hormonally related cancers. Here, in two prospective cohorts, the Nurses’ Health Study II (NHSII), involving women ages 25–42 at baseline, and the Women's Health Study, with women 45 years or older, migraine was assessed for associations specifically with ovarian cancer. Overall, no statistically significant relationship was detected. Stratified analyses in the NHSII cohort revealed a positive association between migraine and ovarian cancer risk in women under age 45.</description><subject>Age</subject><subject>Cancer</subject><subject>Carcinoma, Ovarian Epithelial</subject><subject>Cohort Studies</subject><subject>Estrogens</subject><subject>Female</subject><subject>Headache</subject><subject>Health risk assessment</subject><subject>Health risks</subject><subject>Humans</subject><subject>Invasiveness</subject><subject>Medical personnel</subject><subject>Medical research</subject><subject>Middle Aged</subject><subject>Migraine</subject><subject>Migraine Disorders - epidemiology</subject><subject>Neoplasms, Glandular and Epithelial - epidemiology</subject><subject>Nurses</subject><subject>Nurses - statistics & numerical data</subject><subject>Ovarian cancer</subject><subject>Ovarian carcinoma</subject><subject>Ovarian Neoplasms - epidemiology</subject><subject>Prospective Studies</subject><subject>Risk</subject><subject>Statistical analysis</subject><subject>Statistical models</subject><subject>Surveys and Questionnaires</subject><subject>United States - epidemiology</subject><subject>Women's Health</subject><subject>Womens health</subject><issn>0020-7136</issn><issn>1097-0215</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNp1kcFu1DAQhi0EotvCgRdAljhQDmltx3HiSyW0ArqowAEQR2tiT7pess5iJ4v2xmvwejwJbrdUFInTHP5Pn2bmJ-QJZyecMXHqV_ak5EyJe2TGma4LJnh1n8xyxoqal-qAHKa0YozzismH5EA0WmjZqBmJ7_xlBB-QQnDUhy0kv0WKGz8usffQ02EL0UOgFoLFSKNPXzNHc0zfTzFh-vXjJz1H6Mcl_ThObkcXi2vZFfFlWGN4nu7kj8iDDvqEj2_mEfn8-tWn-Xlx8eHNYv7yorBSlqKoZKdargVYLF3VlFJorSuhOy1QOdW6phbO8Rawc6rRFlrNnRDQImuFtG15RM723s3UrtFZDGOE3myiX0PcmQG8uZsEvzSXw9ZUTaWk4llwfCOIw7cJ02jWPlnsewg4TMlwLfO3WSVFRp_9g66GKYZ8XqZqKWvdaJWpF3vKxiGliN3tMpyZqyZNbtJcN5nZp39vf0v-qS4Dp3vgu-9x93-TWbyd75W_AZNnqdE</recordid><startdate>20180201</startdate><enddate>20180201</enddate><creator>Rice, Megan S.</creator><creator>Rist, Pamela M.</creator><creator>Winter, Anke C.</creator><creator>Kurth, Tobias</creator><creator>Tworoger, Shelley S.</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TO</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-8900-4889</orcidid></search><sort><creationdate>20180201</creationdate><title>Migraine and invasive epithelial ovarian cancer risk in the Nurses’ Health Study II and the Women's Health Study</title><author>Rice, Megan S. ; Rist, Pamela M. ; Winter, Anke C. ; Kurth, Tobias ; Tworoger, Shelley S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4432-54f6b192ace3d58342999529f92e6d6bd872dd1baefd689cab91d22abe0b24cb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Age</topic><topic>Cancer</topic><topic>Carcinoma, Ovarian Epithelial</topic><topic>Cohort Studies</topic><topic>Estrogens</topic><topic>Female</topic><topic>Headache</topic><topic>Health risk assessment</topic><topic>Health risks</topic><topic>Humans</topic><topic>Invasiveness</topic><topic>Medical personnel</topic><topic>Medical research</topic><topic>Middle Aged</topic><topic>Migraine</topic><topic>Migraine Disorders - epidemiology</topic><topic>Neoplasms, Glandular and Epithelial - epidemiology</topic><topic>Nurses</topic><topic>Nurses - statistics & numerical data</topic><topic>Ovarian cancer</topic><topic>Ovarian carcinoma</topic><topic>Ovarian Neoplasms - epidemiology</topic><topic>Prospective Studies</topic><topic>Risk</topic><topic>Statistical analysis</topic><topic>Statistical models</topic><topic>Surveys and Questionnaires</topic><topic>United States - epidemiology</topic><topic>Women's Health</topic><topic>Womens health</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rice, Megan S.</creatorcontrib><creatorcontrib>Rist, Pamela M.</creatorcontrib><creatorcontrib>Winter, Anke C.</creatorcontrib><creatorcontrib>Kurth, Tobias</creatorcontrib><creatorcontrib>Tworoger, Shelley S.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>International journal of cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rice, Megan S.</au><au>Rist, Pamela M.</au><au>Winter, Anke C.</au><au>Kurth, Tobias</au><au>Tworoger, Shelley S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Migraine and invasive epithelial ovarian cancer risk in the Nurses’ Health Study II and the Women's Health Study</atitle><jtitle>International journal of cancer</jtitle><addtitle>Int J Cancer</addtitle><date>2018-02-01</date><risdate>2018</risdate><volume>142</volume><issue>3</issue><spage>534</spage><epage>539</epage><pages>534-539</pages><issn>0020-7136</issn><eissn>1097-0215</eissn><abstract>Migraine is a common primary headache disorder, which predominantly impacts women. Recently, migraine has been hypothesized to be associated with hormonally related cancers; however, the potential association between migraine and ovarian cancer has not been studied. Therefore, we evaluated the association between migraine and invasive epithelial ovarian cancer risk in two prospective cohorts, the Nurses’ Health Study II (NHSII) and the Women's Health Study (WHS). Our prospective analysis included 113,124 NHSII participants aged 25–42 at study baseline as well as 33,490 participants in the WHS who were 45 years or older at study entry. We used Cox proportional hazards models to estimate the hazard ratios (HR) and 95% confidence intervals (CIs) for the association between migraine and ovarian cancer risk in each cohort. In secondary analyses, we stratified by age and menopausal status. After adjusting for potential covariates, there was no statistically significant association between migraine and ovarian cancer risk in either the NHSII (HR = 1.29, 95%CI: 0.96, 1.74) or the WHS (HR = 0.60, 95%CI: 0.34, 1.06). In stratified analysis in the NHSII, there was a statistically significant positive association between migraine and ovarian cancer risk among women <45 years of age (HR = 1.76, 95%CI: 1.01, 3.07). We did not observe a clear association between migraine and ovarian cancer risk in two large prospective cohort studies.
What's new?
Migraine is more common in women than men, giving rise to the idea that hormones, particularly changing estrogen levels, trigger the condition. Recent studies further suggest that migraine may be associated with hormonally related cancers. Here, in two prospective cohorts, the Nurses’ Health Study II (NHSII), involving women ages 25–42 at baseline, and the Women's Health Study, with women 45 years or older, migraine was assessed for associations specifically with ovarian cancer. Overall, no statistically significant relationship was detected. Stratified analyses in the NHSII cohort revealed a positive association between migraine and ovarian cancer risk in women under age 45.</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>28929486</pmid><doi>10.1002/ijc.31062</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0002-8900-4889</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | International journal of cancer, 2018-02, Vol.142 (3), p.534-539 |
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| subjects | Age Cancer Carcinoma, Ovarian Epithelial Cohort Studies Estrogens Female Headache Health risk assessment Health risks Humans Invasiveness Medical personnel Medical research Middle Aged Migraine Migraine Disorders - epidemiology Neoplasms, Glandular and Epithelial - epidemiology Nurses Nurses - statistics & numerical data Ovarian cancer Ovarian carcinoma Ovarian Neoplasms - epidemiology Prospective Studies Risk Statistical analysis Statistical models Surveys and Questionnaires United States - epidemiology Women's Health Womens health |
| title | Migraine and invasive epithelial ovarian cancer risk in the Nurses’ Health Study II and the Women's Health Study |
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