REPLY TO LI VOLTI ET AL: E-cigarette smoke exposure and effect in mice and human cells

Tang explains his study on E-cigarette smoke exposure and effect in mice and human cells. He emphasizes that in their study, the E-cigarette smoke (ECS) was generated by E-juice (nicotine,10 mg/mL) in an E-cigarette (E-cig) machine operated at 4.2 V, the same voltage as a commercial E-cig pen. The E...

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 2018-04, Vol.115 (14), p.E3075-E3076
Main Author: Tang, Moon-shong
Format: Article
Language:English
Subjects:
Aerosols
Animals
Biological Sciences
Cigarette smoke
Deoxyribonucleic acid
DNA
DNA adducts
DNA repair
Electronic cigarettes
Electronic Nicotine Delivery Systems
Exposure
Humans
LETTER
Letters
Lung
Mice
Mice, Inbred C57BL
Nicotiana
Nicotine
Smoke
Smoking
Tobacco smoke
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Summary:Tang explains his study on E-cigarette smoke exposure and effect in mice and human cells. He emphasizes that in their study, the E-cigarette smoke (ECS) was generated by E-juice (nicotine,10 mg/mL) in an E-cigarette (E-cig) machine operated at 4.2 V, the same voltage as a commercial E-cig pen. The ECS concentration was 130 mg/m3 (measured) and the nicotine concentration in the aerosol was 1.3 mg/m3 (assuming nicotine concentration in aerosols is the same as in E-juice). Mice were subject to whole-body exposure. Mouse experiments necessitate using longer exposure times (3 h/d, 12 wk) to allow measurement of ECS's effect on DNA adduct formation and DNA repair activity.
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.1802912115