Physical Activity Dimensions Associated with Impaired Glucose Metabolism

• Published in: Medicine and science in sports and exercise 2017-11, Vol.49 (11), p.2176-2184
• Main Authors: Amadid, Hanan, Johansen, Nanna B, Bjerregaard, Anne-Louise, Vistisen, Dorte, Færch, Kristine, Brage, Søren, Lauritzen, Torsten, Witte, Daniel R, Sandbæk, Annelli, Jørgensen, Marit E
• Format: Article
• Language: English
• Subjects: Aged; Blood Glucose - metabolism; Body Mass Index; Cross-Sectional Studies; Decision Support Techniques; Diabetes Mellitus, Type 2 - prevention & control; Energy Metabolism - physiology; Exercise - physiology; Female; Glucose Intolerance - blood; Heart Rate - physiology; Humans; Male; Middle Aged; Monitoring, Ambulatory; Sedentary Behavior
• ISSN: 0195-9131; 1530-0315
• DOI: 10.1249/MSS.0000000000001362

PURPOSEPhysical activity (PA) is important in the prevention of type 2 diabetes, yet little is known about the role of specific dimensions of PA, including sedentary time in subgroups at risk of impaired glucose metabolism (IGM). We applied a data driven decision tool to identify dimensions of PA associated with IGM across age, sex and body mass index (BMI) groups. METHODSThis cross-sectional study included 1,501 individuals (mean (SD) age 65.6 (6.8) years) at high risk of type 2 diabetes from the ADDITION-PRO study. PA was measured by an individually calibrated combined accelerometer and heart rate monitor worn for 7 days. PA energy expenditure, time spent in different activity intensities, bout duration and sedentary time were considered determinants of IGM together with age, sex and BMI. Decision tree analysis was applied to identify subgroup-specific dimensions of PA associated with IGM. IGM was based on oral glucose tolerance test results and defined as fasting plasma glucose ≥ 6.1 mmol/L and/or 2-hour plasma glucose ≥ 7.8 mmol/L. RESULTSAmong overweight (BMI ≥ 25kg/m) men, accumulating less than 30 minutes/day of moderate-to-vigorous PA was associated with IGM, while in overweight women sedentary time was associated with IGM. Among individuals aged > 53 years with normal weight (BMI < 25kg/m), time spent in light PA was associated with IGM. None of the dimensions of PA were associated with IGM among individuals aged ≤ 53 years with normal weight. CONCLUSIONWe identified subgroups in which different activity dimensions were associated with IGM. Methodology and results from this study may suggest a preliminary step towards the goal of tailoring and targeting PA interventions aimed at type 2 diabetes prevention.