High orange juice consumption with or in-between three meals a day differently affects energy balance in healthy subjects

• Published in: Nutrition & diabetes 2018-04, Vol.8 (1), p.19-9, Article 19
• Main Authors: Hägele, Franziska A, Büsing, Franziska, Nas, Alessa, Aschoff, Julian, Gnädinger, Lena, Schweiggert, Ralf, Carle, Reinhold, Bosy-Westphal, Anja
• Format: Article
• Language: English
• Subjects: 692/699/2743/137/773; 692/699/2743/393; Adipose Tissue - metabolism; Adult; Blood Glucose - metabolism; Body fat; Body Mass Index; Citrus sinensis; Clinical Nutrition; Diabetes; Diabetes Mellitus, Type 2 - blood; Diet; Dietary Sugars - administration & dosage; Dietary Sugars - pharmacology; Energy Intake; Energy Metabolism - drug effects; Epidemiology; Feeding Behavior; Female; Fruit and Vegetable Juices; gamma-Glutamyltransferase - blood; Glucose; Humans; Insulin; Insulin - blood; Insulin Resistance; Internal Medicine; Intervention; Male; Meals; Medicine; Medicine & Public Health; Metabolic Diseases; Metabolism; Postprandial Period; Reference Values; Triglycerides - blood; Young Adult
• ISSN: 2044-4052; 2044-4052
• DOI: 10.1038/s41387-018-0031-3

Sugar-containing beverages like orange juice can be a risk factor for obesity and type 2 diabetes although the underlying mechanisms are less clear. We aimed to investigate if intake of orange juice with or in-between meals differently affects energy balance or metabolic risk. Twenty-six healthy adults (24.7 ± 3.2 y; BMI 23.2 ± 3.2 kg/m 2 ) participated in a 4-week cross-over intervention and consumed orange juice (20% of energy requirement) either together with 3 meals/d (WM) or in-between 3 meals/d (BM) at ad libitum energy intake. Basal and postprandial insulin sensitivity (primary outcome), daylong glycaemia, glucose variability and insulin secretion were assessed. Body fat mass was measured by air-displacement plethysmography. After BM-intervention, fat mass increased (+1.0 ± 1.8 kg; p