How do cells know what shape they are?

Studies on a yeast cell cycle checkpoint that can delay mitosis depending on whether cells have built a bud have identified a “sensor” that seems to recognize the organization of filament-forming septin proteins. Innovative work applying correlative light and platinum replica electron microscopy sug...

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Bibliographic Details
Published in:Current genetics 2017-02, Vol.63 (1), p.75-77
Main Authors: Kang, Hui, Lew, Daniel J.
Format: Article
Language:English
Subjects:
Biochemistry
Biomedical and Life Sciences
Cell Biology
Cell Cycle Proteins - genetics
Cell Cycle Proteins - metabolism
Cytoskeletal Proteins - genetics
Cytoskeletal Proteins - metabolism
electron microscopy
Life Sciences
Microbial Genetics and Genomics
Microbiology
mitosis
Plant Sciences
platinum
proteins
Proteomics
Review
Stress, Physiological
Yeasts
Yeasts - cytology
Yeasts - physiology
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Summary:Studies on a yeast cell cycle checkpoint that can delay mitosis depending on whether cells have built a bud have identified a “sensor” that seems to recognize the organization of filament-forming septin proteins. Innovative work applying correlative light and platinum replica electron microscopy suggests that the informative septin organization involves parallel alignment of septin filaments, and another striking study shows that septin filaments prefer to populate membranes that have positive micron-scale curvature. Together, these findings suggest a model for how cells may monitor aspects of their own shape to influence cell behavior.
ISSN:0172-8083
1432-0983
DOI:10.1007/s00294-016-0623-1