The relationship between mismatch response and the acoustic change complex in normal hearing infants

•Acoustic change complex (ACC) and mismatch response (MMR) can be assessed during sleep in infants.•ACC is not sensitive to measuring speech discrimination in sleeping infants.•MMR is sensitive to measuring speech discrimination in individual sleeping infants. To examine the utility of the mismatch...

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Bibliographic Details
Published in:Clinical neurophysiology 2018-06, Vol.129 (6), p.1148-1160
Main Authors: Uhler, Kristin M., Hunter, Sharon K., Tierney, Elyse, Gilley, Phillip M.
Format: Article
Language:English
Subjects:
Acoustic change complex
Acoustic Stimulation
Discrimination, Psychological - physiology
Evoked Potentials, Auditory - physiology
Female
Hearing loss
Hearing Loss - diagnosis
Hearing Loss - physiopathology
Hearing Tests
Humans
Infant
Male
Mismatched response
Sleep
Speech discrimination
Speech Perception - physiology
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Summary:•Acoustic change complex (ACC) and mismatch response (MMR) can be assessed during sleep in infants.•ACC is not sensitive to measuring speech discrimination in sleeping infants.•MMR is sensitive to measuring speech discrimination in individual sleeping infants. To examine the utility of the mismatch response (MMR) and acoustic change complex (ACC) for assessing speech discrimination in infants. Continuous EEG was recorded during sleep from 48 (24 male, 20 female) normally hearing aged 1.77 to –4.57 months in response to two auditory discrimination tasks. ACC was recorded in response to a three-vowel sequence (/i/-/a/-/i/). MMR was recorded in response to a standard vowel, /a/, (probability 85%), and to a deviant vowel, /i/, (probability of 15%). A priori comparisons included: age, sex, and sleep state. These were conducted separately for each of the three bandpass filter settings were compared (1–18, 1–30, and 1–40 Hz). A priori tests revealed no differences in MMR or ACC for age, sex, or sleep state for any of the three filter settings. ACC and MMR responses were prominently observed in all 44 sleeping infants (data from four infants were excluded). Significant differences observed for ACC were to the onset and offset of stimuli. However, neither group nor individual differences were observed to changes in speech stimuli in the ACC. MMR revealed two prominent peaks occurring at the stimulus onset and at the stimulus offset. Permutation t-tests revealed significant differences between the standard and deviant stimuli for both the onset and offset MMR peaks (p 
ISSN:1388-2457
1872-8952
DOI:10.1016/j.clinph.2018.02.132