Inter-residue, inter-protein and inter-family coevolution: bridging the scales

•Coevolutionary modeling has an immense potential in structural systems biology.•Interaction between two protein families can be detected.•Specific interaction partners inside families can be deduced.•Contact residues between interacting proteins can be predicted.•Predicted inter-protein contacts ca...

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Bibliographic Details
Published in:Current opinion in structural biology 2018-06, Vol.50, p.26-32
Main Authors: Szurmant, Hendrik, Weigt, Martin
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Amino Acids - chemistry
Binding Sites
Databases, Protein
Evolution, Molecular
Life Sciences
Models, Molecular
Multigene Family
Protein Binding
Protein Conformation
Proteins - chemistry
Proteins - genetics
Proteins - metabolism
Quantitative Structure-Activity Relationship
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Summary:•Coevolutionary modeling has an immense potential in structural systems biology.•Interaction between two protein families can be detected.•Specific interaction partners inside families can be deduced.•Contact residues between interacting proteins can be predicted.•Predicted inter-protein contacts can guide in silico protein-complex assembly. Interacting proteins coevolve at multiple but interconnected scales, from the residue–residue over the protein–protein up to the family–family level. The recent accumulation of enormous amounts of sequence data allows for the development of novel, data-driven computational approaches. Notably, these approaches can bridge scales within a single statistical framework. Although being currently applied mostly to isolated problems on single scales, their immense potential for an evolutionary informed, structural systems biology is steadily emerging.
ISSN:0959-440X
1879-033X
DOI:10.1016/j.sbi.2017.10.014