Efficacy of Dural Sealant System for Preventing Brain Shift and Improving Accuracy in Deep Brain Stimulation Surgery

• Published in: Neurologia medico-chirurgica 2018, Vol.58(5), pp.199-205
• Main Authors: SASAKI, Tatsuya, AGARI, Takashi, KUWAHARA, Ken, KIN, Ittetsu, OKAZAKI, Mihoko, SASADA, Susumu, SHINKO, Aiko, KAMEDA, Masahiro, YASUHARA, Takao, DATE, Isao
• Format: Article
• Language: English
• Subjects: Accuracy; brain shift; Deep brain stimulation; dural sealant system; Electrodes; Original; Sealing compounds; Surgery; surgical accuracy
• ISSN: 0470-8105; 1349-8029
• DOI: 10.2176/nmc.oa.2017-0242

The success of deep brain stimulation (DBS) depends heavily on surgical accuracy, and brain shift is recognized as a significant factor influencing accuracy. We investigated the factors associated with surgical accuracy and showed the effectiveness of a dural sealant system for preventing brain shift in 32 consecutive cases receiving DBS. Thirty-two patients receiving DBS between March 2014 and May 2015 were included in this study. We employed conventional burr hole techniques for the first 18 cases (Group I) and a dural sealant system (DuraSeal) for the subsequent 14 cases (Group II). We measured gaps between the actual positions of electrodes and the predetermined target positions. We then retrospectively evaluated the factors involved in surgical accuracy. The average gap between an electrode’s actual and target positions was 1.55 ± 0.83 mm in all cases. Postoperative subdural air volume e, the only factor associated with surgical accuracy (r = 0.536, P < 0.0001), was significantly smaller in Group II (Group I: 43.9 ± 27.7, Group II: 12.1 ± 12.5 ml, P = 0.0006). The average electrode position gap was also significantly smaller in Group II (Group I: 1.77 ± 0.91, Group II: 1.27 ± 0.59 mm, P = 0.035). Use of a dural sealant system could significantly reduce intracranial air volume, which should improve surgical accuracy.