The relationship between interleukin-6 and functional connectivity in methamphetamine users

•Interleukin 6 (IL-6) levels are higher in methamphetamine (MA) users than in controls.•Relationships between functional connectivity (FC) and IL-6 differ by group.•Striatolimbic FC and IL-6: positively related in MA users but negatively in controls.•Corticostriatal FC and IL-6: unrelated in control...

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Bibliographic Details
Published in:Neuroscience letters 2018-06, Vol.677, p.49-54
Main Authors: Kohno, Milky, Loftis, Jennifer M., Huckans, Marilyn, Dennis, Laura E., McCready, Holly, Hoffman, William F.
Format: Article
Language:English
Subjects:
Adult
Amphetamine-Related Disorders - complications
Amphetamine-Related Disorders - physiopathology
Brain - drug effects
Brain - physiopathology
Brain Mapping
Corticostriatal
Female
Humans
IL-6
Inflammation
Inflammation - blood
Inflammation - chemically induced
Interleukin-6 - blood
Magnetic Resonance Imaging
Male
Mesocorticolimbic
Methamphetamine
Methamphetamine - adverse effects
Neural Pathways - drug effects
Neural Pathways - physiopathology
Resting-state functional connectivity
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Summary:•Interleukin 6 (IL-6) levels are higher in methamphetamine (MA) users than in controls.•Relationships between functional connectivity (FC) and IL-6 differ by group.•Striatolimbic FC and IL-6: positively related in MA users but negatively in controls.•Corticostriatal FC and IL-6: unrelated in controls and negatively related in MA users. Methamphetamine (MA) causes an increase in pro-inflammatory cytokines in animal models and in humans. Resulting activation of microglia and neuro-inflammation could, via effects on reward networks, mediate behavioral characteristics of addiction. We examined the relationship between interleukin-6 (IL-6) and corticolimbic and striatolimbic resting-state functional connectivity (RSFC). Thirty adults diagnosed with MA dependence and 20 control subjects underwent a resting-state functional magnetic resonance imaging (fMRI) scan and gave a blood sample for determination of plasma IL-6 levels. Seed-based RSFC analyses were performed to examine the interactive effect of group and IL-6 on ventral striatal and prefrontal connectivity. Within the MA group, IL-6 levels were positively related to striatolimbic RSFC but negatively related to corticostriatal RSFC. Our findings with IL-6 support the idea that inflammation may at least partly mediate the link among MA use disorder, RSFC, and behavior, possibly via effects on mesolimbic and mesocortical dopaminergic systems.
ISSN:0304-3940
1872-7972
DOI:10.1016/j.neulet.2018.04.037