Effects of Polylactide Copolymer Implants and Platelet-Rich Plasma on Bone Regeneration within a Large Calvarial Defect in Sheep

The aim of this study was to verify whether L-lactide/DL-lactide copolymer 80/20 (PLDLLA) and platelet-rich plasma (PRP) trigger bone formation within critical-sized calvarial defects in adult sheep ( n = 6 ). Two craniectomies, each ca. 3 cm in diameter, were created in each animal. The first crani...

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Bibliographic Details
Published in:BioMed research international 2018-01, Vol.2018 (2018), p.1-11
Main Authors: Ładziński, Piotr, Bursig, Henryk, Grajoszek, Aniela, Stodolak-Zych, Ewa, Binkowski, Marcin, Kajor, Maciej, Ficek, Krzysztof, Kaspera, Wojciech, Błaszczyk, Bartłomiej, Stojko, Jerzy
Format: Article
Language:English
Subjects:
Animals
Biocompatibility
Biomedical materials
Biomedical research
Bone growth
Bone healing
Bone implants
Bone marrow
Bone Regeneration - drug effects
Bone surgery
Defects
Ethylenediaminetetraacetic acid
Growth factors
Hot pressing
Membranes, Artificial
Nanocomposites
Neurosurgery
Osteogenesis
Platelet-Rich Plasma
Platelets
Polyesters - chemistry
Polyesters - pharmacology
Polylactic acid
Polymers
Polymethyl methacrylate
Regeneration
Regeneration (physiology)
Sheep
Skin & tissue grafts
Skull - injuries
Skull - metabolism
Skull - pathology
Stem cells
Studies
Surgery
Surgical implants
Synthetic products
Tensile strength
Tissue engineering
Transplants & implants
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Summary:The aim of this study was to verify whether L-lactide/DL-lactide copolymer 80/20 (PLDLLA) and platelet-rich plasma (PRP) trigger bone formation within critical-sized calvarial defects in adult sheep ( n = 6 ). Two craniectomies, each ca. 3 cm in diameter, were created in each animal. The first craniectomy was protected with an inner polylactide membrane, filled with PRP-polylactide granules, and covered with outer polylactide membrane. The second control craniectomy was left untreated. The animals were euthanized at 6, 7, 17, 19, 33, and 34 weeks after surgery, and the quality and the rate of reossification were assessed histomorphometrically and microtomographically. The study demonstrated that application of implants made of PLDLLA 80/20 combined with an osteopromotive substance (e.g., PRP) may promote bone healing in large calvarial defect in sheep. These promising proof-of-concept studies need to be verified in the future on a larger cohort of animals and over a longer period of time in order to draw definitive conclusions.
ISSN:2314-6133
2314-6141
DOI:10.1155/2018/4120471