Regulation of lipid peroxidation and ferroptosis in diverse species

Lipid peroxidation is the process by which oxygen combines with lipids to generate lipid hydroperoxides via intermediate formation of peroxyl radicals. Vitamin E and coenzyme Q react with peroxyl radicals to yield peroxides, and then these oxidized lipid species can be detoxified by glutathione and...

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Bibliographic Details
Published in:Genes & development 2018-05, Vol.32 (9-10), p.602-619
Main Authors: Conrad, Marcus, Kagan, Valerian E, Bayir, Hülya, Pagnussat, Gabriela C, Head, Brian, Traber, Maret G, Stockwell, Brent R
Format: Article
Language:English
Subjects:
Animals
Antioxidants - metabolism
Biological Evolution
Cell Death - physiology
Humans
Iron - metabolism
Lipid Peroxidation
Reactive Oxygen Species - metabolism
Review
Species Specificity
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Summary:Lipid peroxidation is the process by which oxygen combines with lipids to generate lipid hydroperoxides via intermediate formation of peroxyl radicals. Vitamin E and coenzyme Q react with peroxyl radicals to yield peroxides, and then these oxidized lipid species can be detoxified by glutathione and glutathione peroxidase 4 (GPX4) and other components of the cellular antioxidant defense network. Ferroptosis is a form of regulated nonapoptotic cell death involving overwhelming iron-dependent lipid peroxidation. Here, we review the functions and regulation of lipid peroxidation, ferroptosis, and the antioxidant network in diverse species, including humans, other mammals and vertebrates, plants, invertebrates, yeast, bacteria, and archaea. We also discuss the potential evolutionary roles of lipid peroxidation and ferroptosis.
ISSN:0890-9369
1549-5477
DOI:10.1101/gad.314674.118