REPLY TO QUEIMADO ET AL: E-cigarettes induce DNA damage and inhibit DNA repair in mice and human cells

Tang discusses several key details in their study about e-cigarettes impact on mice and human cells that Queimado et al may have missed. He clarifies that their study treated human cells with pure nicotine or with the nicotine-derived nitrosamine ketone (NKK), not E-cigarette smoke. Therefore, all e...

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 2018-06, Vol.115 (24), p.E5439-E5439
Main Author: Tang, Moon-shong
Format: Article
Language:English
Subjects:
4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone
Animals
Biological Sciences
Cells
Cigarette smoke
Cigarettes
Deoxyribonucleic acid
DNA
DNA adducts
DNA Damage
DNA Repair
Electronic cigarettes
Electronic Nicotine Delivery Systems
Genotoxicity
Humans
LETTER
Letters
Mice
Nicotine
Nitrosamine
Repair
Smoke
Smoking
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Summary:Tang discusses several key details in their study about e-cigarettes impact on mice and human cells that Queimado et al may have missed. He clarifies that their study treated human cells with pure nicotine or with the nicotine-derived nitrosamine ketone (NKK), not E-cigarette smoke. Therefore, all effects on DNA adduct formation and DNA repair activity are unambiguously due to nicotine and NNK exposure, and thus are not derived from other electronic cigarette genotoxic components, as suggested by Queimado et al.
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.1807971115