Usefulness of the Serial Measurement of Vi Antibodies

In a secondary analysis of a published immunogenicity trial comparing Vi capsular polysaccharide vaccine with a similar dose (25 µg) conjugated to tetanus toxoid, Voysey and Pollard have succeeded in not only establishing an argument that serial measurement of Vi antibodies are a marker of typhoid e...

Full description

Saved in:
Bibliographic Details
Published in:Clinical infectious diseases 2018-06, Vol.67 (1), p.25-26
Main Author: Klugman, Keith P
Format: Article
Language:English
Subjects:
and Commentaries
Antibodies
Capsular polysaccharides
Data processing
Exposure
Immunogenicity
Polysaccharides
Secondary analysis
Tetanus
Typhoid
Vaccines
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:In a secondary analysis of a published immunogenicity trial comparing Vi capsular polysaccharide vaccine with a similar dose (25 µg) conjugated to tetanus toxoid, Voysey and Pollard have succeeded in not only establishing an argument that serial measurement of Vi antibodies are a marker of typhoid exposure but have also paved the way for future conjugate typhoid vaccines to be evaluated in endemic settings at a fraction of the recruitment required for traditional typhoid efficacy trials. The key to their observations came from extending the analysis of the data from the trial beyond the initial immunogenicity timepoint of 6 weeks postimmunization, to consider further time points 18 months and 2 years after the initial vaccines were administered. The authors’ posit that these Vi antigen exposures are symptomatic or asymptomatic episodes of typhoid infection.
ISSN:1058-4838
1537-6591
DOI:10.1093/cid/cix1151