Uremia increases QRS duration after β‐adrenergic stimulation in mice

Chronic kidney disease (CKD) and uremia increase the risk of heart disease and sudden cardiac death. Coronary artery disease can only partly account for this. The remaining mechanistic links between CKD and sudden death are elusive, but may involve cardiac arrhythmias. For the present study, we hypo...

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Bibliographic Details
Published in:Physiological reports 2018-07, Vol.6 (13), p.e13720-n/a
Main Authors: Thomsen, Morten B., Nielsen, Morten S., Aarup, Annemarie, Bisgaard, Line S., Pedersen, Tanja X.
Format: Article
Language:English
Subjects:
Arrhythmia
Cardiac arrhythmia
Cardiovascular Conditions, Disorders and Treatments
Cardiovascular disease
Conduction
Conduction velocity
Connexin 43
Coronary artery
Coronary artery disease
Death
Diurnal
Echocardiography
EKG
electrocardiogram
Electrocardiography
Electrophysiological recording
Gap junctions
Kidney
Kidney diseases
Kidneys
Nephrectomy
Original Research
Physiology
Renal Conditions, Disorders and Treatments
renal disease
sympathetic
Transcription
Urea
Uremia
Ventricle
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Summary:Chronic kidney disease (CKD) and uremia increase the risk of heart disease and sudden cardiac death. Coronary artery disease can only partly account for this. The remaining mechanistic links between CKD and sudden death are elusive, but may involve cardiac arrhythmias. For the present study, we hypothesized that a thorough electrophysiological study in mice with CKD would provide us valuable information that could aid in the identification of additional underlying causes of sudden cardiac death in patients with kidney disease. Partial (5/6) nephrectomy (NX) in mice induced mild CKD: plasma urea in NX was 24 ± 1 mmol/L (n = 23) versus 12 ± 1 mmol/L (n = 22) in sham‐operated control mice (P 
ISSN:2051-817X
DOI:10.14814/phy2.13720