Association of MMP-2 (⁻1306 C/T) Gene Polymorphism with Predisposition to Optic Neuritis and Optic Neuritis Together with Multiple Sclerosis

• Published in: Medicina (Kaunas, Lithuania) Lithuania), 2018-05, Vol.54 (2), p.29
• Main Authors: Liutkevičienė, Rasa, Vilkevičiūtė, Alvita, Banevičus, Mantas, Miežytė, Raminta, Kriaučiūnienė, Loresa
• Format: Article
• Language: English
• ISSN: 1648-9144; 1010-660X; 1648-9144
• DOI: 10.3390/medicina54020029

Optic neuritis (ON) is characterized by painful, usually monocular vision loss with decreased visual acuity and defects of the visual field and color vision. The etiology and pathophysiology of ON is not completely clear. It is thought that a matrix metalloproteinase 2 ( gene plays an essential role in this autoimmune inflammatory disease. The aim of this study was to determine the relationship between the gene polymorphism and ON, and that of ON with multiple sclerosis. Patients with ON/ON and multiple sclerosis and a control group of healthy individuals were enrolled in this study. The genotyping test of the was carried out using a real-time polymerase chain reaction (PCR) method. Analysis revealed that T allele at the (-1306 C/T) was less frequent in the ON group compared to the control group (14.5% vs. 23.3%, = 0.031), and was associated with decreased likelihood of ON development (OR = 0.566; 95% CI: 0.333-0.962; = 0.036). No significant associations were revealed while comparing the subgroups of ON patients with and without multiple sclerosis. The (-1306 C/T) gene polymorphism was found to be associated with ON development.