Pericytes constrict blood vessels after myocardial ischemia

No-reflow phenomenon is defined as the reduced blood flow after myocardial ischemia. If prolonged it leads to profound damages in the myocardium. The lack of a detailed knowledge about the cells mediating no-reflow restricts the design of effective therapies. Recently, O'Farrell et al. (2017) b...

Full description

Saved in:
Bibliographic Details
Published in:Journal of molecular and cellular cardiology 2018-03, Vol.116, p.1-4
Main Authors: Costa, Matheus A., Paiva, Ana E., Andreotti, Julia P., Cardoso, Marcus V., Cardoso, Carlos D., Mintz, Akiva, Birbrair, Alexander
Format: Article
Language:English
Subjects:
Animals
Disease Models, Animal
Heart
Humans
Ischemia
Myocardial Ischemia - pathology
Myocardial Ischemia - physiopathology
Pericytes
Pericytes - pathology
Vasoconstriction
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:No-reflow phenomenon is defined as the reduced blood flow after myocardial ischemia. If prolonged it leads to profound damages in the myocardium. The lack of a detailed knowledge about the cells mediating no-reflow restricts the design of effective therapies. Recently, O'Farrell et al. (2017) by using state-of-the-art technologies, including high-resolution confocal imaging in combination with myocardial ischemia/reperfusion mouse model, reveal that pericytes contribute to the no-reflow phenomenon post-ischemia in the heart. Strikingly, intravenous adenosine increased vascular diameter at pericyte site after cardiac ischemia. This study provides a novel therapeutic target to inhibit no-reflow phenomenon after myocardial ischemia.
ISSN:0022-2828
1095-8584
DOI:10.1016/j.yjmcc.2018.01.014