Animal tests for anxiety-like and depression-like behavior in rats

An animal model of human behavior represents a complex of cognitive and/or emotional processess, which are translated from animals to humans. A behavioral test is developed primarily and specifically to verify and support a theory of cognition or emotion; it can also be used to verify a theory of a...

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Bibliographic Details
Published in:Interdisciplinary toxicology 2017-09, Vol.10 (1), p.40-43
Main Authors: Belovicova, Kristina, Bogi, Eszter, Csatlosova, Kristina, Dubovicky, Michal
Format: Article
Language:English
Subjects:
Anxiety
Behavior
Cognition
Cognitive ability
depression
Drug discovery
Human behavior
Hyperthermia
Mental depression
Open-field behavior
Psychopathology
rat
Rats
Short Communication
Sucrose
Sugar
tests
Toxicology
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Summary:An animal model of human behavior represents a complex of cognitive and/or emotional processess, which are translated from animals to humans. A behavioral test is developed primarily and specifically to verify and support a theory of cognition or emotion; it can also be used to verify a theory of a psychopathology, but it is not developed for a particular type of psychopathology. The paper reviews tests commonly used in novel drug discovery research. Focus is especially on tests which can evaluate anxiety-like (open-field test, novelty suppressed feeding, elevated plus maze, light/dark box, stressinduced hyperthermia) and depression-like behaviors (forced swim test, tail suspension test, sucrose preference test) as they represent an important methodological tool in pre-clinical as well as in behavioral toxicology studies.
ISSN:1337-6853
1337-9569
1337-9569
DOI:10.1515/intox-2017-0006