Coronary artery calcification score and common iliac artery calcification score in non‐dialysis CKD patients

• Published in: Nephrology (Carlton, Vic.) Vic.), 2018-09, Vol.23 (9), p.837-845
• Main Authors: Mizuiri, Sonoo, Nishizawa, Yoshiko, Yamashita, Kazuomi, Mizuno, Kenji, Ishine, Masahiro, Doi, Shigehiro, Masaki, Takao, Shigemoto, Kenichiro
• Format: Article
• Language: English
• Subjects: Adult; Age; Aged; Aged, 80 and over; Calcification; Calcification (ectopic); chronic kidney disease; common iliac artery; Computed tomography; Computed Tomography Angiography; Coronary Angiography - methods; Coronary artery; coronary artery calcification score; Coronary Artery Disease - complications; Coronary Artery Disease - diagnostic imaging; Coronary vessels; Diabetes; Diabetes mellitus; Dialysis; Disease Progression; Epidermal growth factor receptors; Female; Femoral Artery - diagnostic imaging; Glomerular filtration rate; Humans; Kidney diseases; Kidneys; Male; medial calcification; Middle Aged; Multidetector Computed Tomography; Original; Peripheral Arterial Disease - complications; Peripheral Arterial Disease - diagnostic imaging; Predictive Value of Tests; Prognosis; Renal Insufficiency, Chronic - complications; Renal Insufficiency, Chronic - diagnosis; Renal Insufficiency, Chronic - physiopathology; Renal Insufficiency, Chronic - therapy; Renal Replacement Therapy; Risk factors; Severity of Illness Index; vascular calcification; Vascular Calcification - complications; Vascular Calcification - diagnostic imaging
• ISSN: 1320-5358; 1440-1797
• DOI: 10.1111/nep.13113

Summary at a Glance Vascular calcification is a major contributor to morbidity and mortality in patients with CKD, although the optimal method and site for measurement of vascular calcification have not been determined. This study assesses and compares coronary artery calcification and common iliac artery calcification determined by CT in a cohort of non‐dialysis CKD patients and reports on associated variables and outcomes. Aim Many studies have validated Agatston’s coronary artery calcification score (CACS) for assessing vascular calcification (VC) in chronic kidney disease (CKD) patients. This study aimed to evaluate the CACS and common iliac artery calcification score (IACS) and to examine the variables related to each score. Methods The subjects were 145 non‐dialysis CKD patients. The CACS and IACS were determined using the same thoracicoabdominal multi‐detector computed tomography. Multiple regression analyses were performed to assess the factors associated with the CACS or IACS. The associations between progression to renal replacement therapy (RRT) and the CACS or IACS were studied using Cox hazards models. Results The subjects’ median age, estimated glomerular filtration rate (eGFR), and follow‐up period were 72 (62–78) years, 32 (18–50) mL/min/1.73m2, and 864 (550–1425) days, respectively. Age, diabetes, the serum phosphate level, and the eGFR were found to be significant factors of the CACS [β (95% CI): 0.38 (0.02–0.04), P