It’s All in the Delivery: Designing Hydrogels for Cell and Non-viral Gene Therapies

Hydrogels provide a regenerative medicine platform with their ability to create an environment that supports transplanted or endogenous infiltrating cells and enables these cells to restore or replace the function of tissues lost to disease or trauma. Furthermore, these systems have been employed as...

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Bibliographic Details
Published in:Molecular therapy 2018-09, Vol.26 (9), p.2087-2106
Main Authors: Youngblood, Richard L., Truong, Norman F., Segura, Tatiana, Shea, Lonnie D.
Format: Article
Language:English
Subjects:
Animals
Biocompatibility
Biodegradation
Biomedical materials
Cell adhesion & migration
cell delivery
Clinical trials
Collagen
Deoxyribonucleic acid
Design
DNA
Engraftment
gene delivery
Gene expression
Gene transfer
Gene Transfer Techniques
Genetic engineering
Humans
Hydrogels
Mechanical properties
Polyethylene glycol
Proteins
Recovery of function
Regenerative medicine
Regenerative Medicine - methods
Regulatory approval
Review
Spinal cord
Stem cells
Tissue engineering
Tissue Engineering - methods
Transplants & implants
Trauma
Vascular endothelial growth factor
Wound healing
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Summary:Hydrogels provide a regenerative medicine platform with their ability to create an environment that supports transplanted or endogenous infiltrating cells and enables these cells to restore or replace the function of tissues lost to disease or trauma. Furthermore, these systems have been employed as delivery vehicles for therapeutic genes, which can direct and/or enhance the function of the transplanted or endogenous cells. Herein, we review recent advances in the development of hydrogels for cell and non-viral gene delivery through understanding the design parameters, including both physical and biological components, on promoting transgene expression, cell engraftment, and ultimately cell function. Furthermore, this review identifies emerging opportunities for combining cell and gene delivery approaches to overcome challenges to the field. [Display omitted] Hydrogels offer great promise in developing suitable environments for both transplanted cell survival and control over gene delivery to promote tissue repair. We review hydrogel design parameters that are available to enhance cell function and the challenges and progress in the incorporation of non-viral vectors to improve therapeutic outcomes.
ISSN:1525-0016
1525-0024
DOI:10.1016/j.ymthe.2018.07.022