One-Pot Facile Fabrication of Bioavailable Iron Nanoparticles with Good Biocompatibility for Anemia Therapy

BACKGROUND Iron deficiency anemia (IDA) has been a major public health problem all over the world. Developing new iron (Fe) fortificants with both high bioavailability and negligible food sensory changes for IDA is in urgent demand. MATERIAL AND METHODS The Fe nanoparticles were fabricated through a...

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Bibliographic Details
Published in:Medical science monitor 2018-09, Vol.24, p.6449-6455
Main Authors: Gu, Yuling, Li, Yunlong, Yang, Yuan, Luo, Qi, Zhang, Ying, Zhou, Chenmin
Format: Article
Language:English
Subjects:
3T3 Cells
Anemia - therapy
Anemia, Iron-Deficiency - therapy
Animals
Biological Availability
Cell Line, Tumor
Dietary Supplements
Iron - blood
Iron - metabolism
Iron - therapeutic use
Lab/In Vitro Research
Materials Testing - methods
Metal Nanoparticles - chemistry
Metal Nanoparticles - therapeutic use
Mice
Nanoparticles - chemistry
Serum Albumin, Bovine - chemistry
Solubility
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Summary:BACKGROUND Iron deficiency anemia (IDA) has been a major public health problem all over the world. Developing new iron (Fe) fortificants with both high bioavailability and negligible food sensory changes for IDA is in urgent demand. MATERIAL AND METHODS The Fe nanoparticles were fabricated through a one-pot reduction process under the protection of bovine serum albumin (BSA). The BSA-Fe nanoparticles were characterized systematically. The comparisons between BSA-Fe nanoparticles and FeSO4 in bioavailability were carried out through hemoglobin (Hb) repletion method. The biocompatibility of BSA-Fe nanoparticles was also investigated through in vitro and in vivo assays. RESULTS BSA-Fe nanoparticles have super-small size and good water solubility as well as water stability. The Hb repletion assay demonstrated that BSA-Fe nanoparticles have comparative bioavailability with FeSO4. The in vitro cell viability assay, in vivo histological analysis, and biochemical measurements proved the remarkable biocompatibility of BSA-Fe nanoparticles. CONCLUSIONS The BSA-Fe nanoparticles fabricated through a one-pot facile method have good water solubility, comparative bioavailability with FeSO4, and acceptable biocompatibility, exhibiting good potential for further clinical translations.
ISSN:1643-3750
1234-1010
1643-3750
DOI:10.12659/MSM.909591