First Clinical Isolation of an Azole-Resistant Aspergillus fumigatus Isolate Harboring a TR46 Y121F T289A Mutation in South America

One of the most recently described -mediated azole resistance mechanisms is TR46 Y121F T289A. Clinical strains harboring these substitutions have been reported worldwide, with the exception of South America. We describe the first clinical strain with this resistance mechanism isolated from an Argent...

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Bibliographic Details
Published in:Antimicrobial agents and chemotherapy 2018-10, Vol.62 (10)
Main Authors: Isla, Guillermina, Leonardelli, Florencia, Tiraboschi, Iris N, Refojo, Nicolás, Hevia, Alejandra, Vivot, Walter, Szusz, Wanda, Córdoba, Susana B, García-Effron, Guillermo
Format: Article
Language:English
Subjects:
Antifungal Agents
Aspergillus fumigatus
Azoles
Mechanisms of Resistance
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Summary:One of the most recently described -mediated azole resistance mechanisms is TR46 Y121F T289A. Clinical strains harboring these substitutions have been reported worldwide, with the exception of South America. We describe the first clinical strain with this resistance mechanism isolated from an Argentinian patient. The strain was isolated in 2009 (1 year after the first-described mutant in United States), demonstrating that these alleles were scattered worldwide earlier than previously thought.
ISSN:0066-4804
1098-6596
DOI:10.1128/AAC.00872-18