The remarkable legacy of a father’s diet on the health of his offspring

Fleming examines the remarkable legacy of a father's diet on the health of his offspring. He notes the recognition of the Barker hypothesis, more known as the Developmental Origins of Health and Disease (DOHaD), that maternal factors such as poor diet and physiological condition could adversely...

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 2018-10, Vol.115 (40), p.9827-9829
Main Author: Fleming, Tom P.
Format: Article
Language:English
Subjects:
Biological Sciences
Birth control
Commentaries
COMMENTARY
Design of experiments
Diet
Experimental design
Fathers
Health risks
Humans
Low protein diet
Male
Nutrient deficiency
Nutrition
Offspring
Physiological effects
Plasma
Pregnancy
Progeny
Proteins
Semen
Sperm
Undernutrition
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Summary:Fleming examines the remarkable legacy of a father's diet on the health of his offspring. He notes the recognition of the Barker hypothesis, more known as the Developmental Origins of Health and Disease (DOHaD), that maternal factors such as poor diet and physiological condition could adversely influence pregnancy and contribute to offspring risk of cardiometabolic disease in adulthood. Fleming comments on a study by Watkins et al on paternal programming of offspring disease in a mouse model of low-protein diet (LPD) undernutrition and show, through an elegant experimental design, that paternal sperm and seminal plasma each exert specific yet coordinated pathways by which fathers influence the well-being of their progeny.
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.1813731115