Exhaustive Exercise Does Not Affect Humoral Immunity and Protection after Rabies Vaccination in a Mouse Model

Rabies is one of the most dangerous and widespread zoonosis and is characterized by severe neurological signs and a high case-mortality rate of nearly 100%. Vaccination is the most effective way to prevent rabies in humans and animals. In this study, the relationship between exhaustive exercise and...

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Bibliographic Details
Published in:Virologica Sinica 2018-06, Vol.33 (3), p.241-248
Main Authors: Xia, Lun, Li, Minrui, Zhang, Yajing, Ruan, Juncheng, Pei, Jie, Shi, Jiale, Fu, Zhen F., Zhao, Ling, Zhou, Ming, Tian, Dayong
Format: Article
Language:English
Subjects:
Animals
Antibodies, Viral - immunology
Biochemistry
Biomedical and Life Sciences
Biomedicine
Cell Line
Cricetinae
Disease Models, Animal
Female
Humoral immunity
Immune response (humoral)
Immunity, Humoral - immunology
Immunization - methods
Lyssavirus
Medical Microbiology
Mice
Microbial Genetics and Genomics
Microbiology
Oncology
Rabies
Rabies - immunology
Rabies - prevention & control
Rabies Vaccines - therapeutic use
Rabies virus - immunology
Research Article
Vaccination
Vaccination - methods
Vaccines
Vaccines, Inactivated - therapeutic use
Virology
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Summary:Rabies is one of the most dangerous and widespread zoonosis and is characterized by severe neurological signs and a high case-mortality rate of nearly 100%. Vaccination is the most effective way to prevent rabies in humans and animals. In this study, the relationship between exhaustive exercise and the humoral immune response after immunization with inactivated rabies vaccine was investigated in a mouse model with one-time exhaustive exercise. It was found that compared with the mice with no exercise after vaccination, no significant differences were found in those with exhaustive exercise after vaccination on body-weight changes, virus-neutralizing antibody (VNA) titers, antibody subtypes and survivor ratio after lethal rabies virus (RABV) challenge. This study indicated that exhaustive exercise does not reduce the effects of the rabies inactivated vaccine.
ISSN:1674-0769
1995-820X
DOI:10.1007/s12250-018-0026-1