Metabolomics Analysis of the Lipid-Regulating Effect of Allium hookeri in a Hamster Model of High-Fat Diet-Induced Hyperlipidemia by UPLC/ESI-Q-TOF Mass Spectrometry

Hyperlipidemia is a risk factor for atherosclerotic cardiovascular disease and is a major public health concern. Allium hookeri (AH) is an Allium species containing high levels of bioactive organosulfur compounds such as methiin and cycloalliin. AH exerts hypolipidemic effects in animals fed a high-...

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Bibliographic Details
Published in:Evidence-based complementary and alternative medicine 2018-01, Vol.2018 (2018), p.1-8
Main Authors: Lee, Sanghee, Choi, Jung Hoon, Yoo, Miyoung, Hur, Haeng Jeon, Sung, Mi Jeong, Jang, Gwang-Ju, Hwang, In Koo
Format: Article
Language:English
Subjects:
Allium hookeri
Amino acids
Analysis
Antilipemic agents
Arteriosclerosis
Bioindicators
Biomarkers
Blood lipids
Cardiovascular disease
Cardiovascular diseases
Chemical compounds
Cholesterol
Chromatography
Diet
Fatty acids
Hamsters
Health risks
High fat diet
Hyperlipidemia
Lipids
Lipoproteins
Liquid chromatography
Mass spectrometry
Mass spectroscopy
Membrane lipids
Metabolism
Metabolites
Metabolomics
Natural products
Nutrition research
Organosulfur compounds
Phospholipids
Public health
Quadrupoles
Risk factors
Rodents
Scientific imaging
Sulfur
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Summary:Hyperlipidemia is a risk factor for atherosclerotic cardiovascular disease and is a major public health concern. Allium hookeri (AH) is an Allium species containing high levels of bioactive organosulfur compounds such as methiin and cycloalliin. AH exerts hypolipidemic effects in animals fed a high-fat diet. However, there exists little information on the mechanisms underlying these effects. To address this issue, we used a metabolomic approach based on ultra-performance liquid chromatography quadrupole time-of-flight mass spectrometry to identify factors mediating the lipid-lowering effects of AH. Principal component and partial least-squares discriminant analyses of serum metabolome profiles revealed 25 metabolites as potential biomarkers for the effects of AH on lipid levels. These compounds were predominantly phospholipids, including phosphatidylcholines (PCs), lysoPCs, and lysophosphatidylethanolamines. Glycerophospholipid metabolism was identified as a significantly enriched pathway. These results provide mechanistic insight into the antihyperlipidemic effects of AH and evidence for its efficacy as a therapeutic agent.
ISSN:1741-427X
1741-4288
DOI:10.1155/2018/5659174