Is It Possible to Develop Cancer Vaccines to Neoantigens, What Are the Major Challenges, and How Can These Be Overcome? Targeting the Right Antigens in the Right Patients

Recent advances in genomic sequencing and bioinformatics have empowered a revolution in immuno-oncology that has led to numerous unambiguous demonstrations of spontaneous and therapy-induced T-cell responses in patients against a subset of immunogenic tumor-specific somatic mutations known as neoant...

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Bibliographic Details
Published in:Cold Spring Harbor perspectives in biology 2018-11, Vol.10 (11), p.a028837
Main Author: Schoenberger, Stephen P
Format: Article
Language:English
Subjects:
Antigens
Antigens, Viral - immunology
Bioinformatics
Cancer immunotherapy
Cancer vaccines
Cancer Vaccines - administration & dosage
Cancer Vaccines - immunology
Drug delivery systems
Humans
Immunogenicity
Immunotherapy
Lymphocytes T
Mutation
Neoantigens
Neoplasms - therapy
Patients
Precision Medicine
T-Lymphocytes
Tumors
Vaccines
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Summary:Recent advances in genomic sequencing and bioinformatics have empowered a revolution in immuno-oncology that has led to numerous unambiguous demonstrations of spontaneous and therapy-induced T-cell responses in patients against a subset of immunogenic tumor-specific somatic mutations known as neoantigens. These findings raise the exciting possibility that patients could be therapeutically treated with personalized vaccines against the mutations expressed by their own tumor. A central challenge for the broader clinical application of this approach will be to define the best antigens to target, to determine the subset of patients most likely to derive significant clinical benefit, and, finally, to discover both the best method of vaccine delivery and the optimal time in the disease course to do so. A growing number of translational immunologists believe that these challenges can be overcome and this perspective will discuss strategies to achieve this.
ISSN:1943-0264
1943-0264
DOI:10.1101/cshperspect.a028837