Repeatability of language fMRI lateralization and localization metrics in brain tumor patients

• Published in: Human brain mapping 2018-12, Vol.39 (12), p.4733-4742
• Main Authors: Agarwal, Shruti, Hua, Jun, Sair, Haris I, Gujar, Sachin, Bettegowda, Chetan, Lu, Hanzhang, Pillai, Jay J
• Format: Article
• Language: English
• Subjects: Activation; Adult; Brain; Brain cancer; Brain mapping; Brain Mapping - methods; Brain Neoplasms - diagnostic imaging; Brain Neoplasms - physiopathology; Brain tumors; Broca Area - diagnostic imaging; Broca Area - physiopathology; Broca's area; Frontal lobe; Functional Laterality - physiology; Functional magnetic resonance imaging; Hemispheric laterality; Humans; Language; Localization; Magnetic Resonance Imaging; Patients; Reproducibility; Tumors; Wernicke Area - diagnostic imaging; Wernicke Area - physiopathology; Wernicke's area
• ISSN: 1065-9471; 1097-0193; 1097-0193
• DOI: 10.1002/hbm.24318

To assess the within-subject intra-scan session repeatability of language functional MRI (fMRI) activation maps in patients with brain tumors who were undergoing presurgical fMRI as part of their preoperative clinical workup. Sentence completion (SC) and silent word generation (SWG) tasks were used for language localization and hemispheric lateralization for identifying the primary language cortex. Within-subject repeatability for each of these paradigms was assessed in right-handed patients-37 for SC and 78 for SWG. Repeatability of activation maps between consecutive runs of the same task within the same scan session was evaluated by comparing lateralization indexes in holohemispheric and regional language areas. Displacement of center of activation between consecutive runs was also used to assess the repeatability of activation maps. Holohemispheric and regional language lateralization results demonstrated high intra-subject intra-scan repeatability when lateralization indices were calculated using threshold-dependent and threshold-independent approaches. The high repeatability is demonstrated both when centers of mass of activation are considered within key eloquent regions of the brain, such as Broca's area and Wernicke's area, as well as in larger more inclusive expressive and receptive language regions. We examined two well-known and widely accepted language tasks that are known to activate eloquent language cortex. We have demonstrated very high degree of repeatability at a single-subject level within single scan sessions of language mapping in a large cohort of brain tumor patients undergoing presurgical fMRI across several years at our institution.