PERCEIVED PHYSICAL AND MENTAL FATIGABILITY: NEW INSIGHTS INTO CONTRIBUTORS AND CONSEQUENCES

• Published in: Innovation in aging 2018-11, Vol.2 (suppl_1), p.199-199
• Main Authors: Glynn, N W, Simonsick, E M, Schrack, J A
• Format: Article
• Language: English
• Subjects: Abstracts
• ISSN: 2399-5300; 2399-5300
• DOI: 10.1093/geroni/igy023.731

Characterizing physical and mental fatigability allows researchers to describe an individual’s susceptibility to experiencing fatigue in the context of a quantifiable demand (physical and/or cognitive) at a fixed intensity and duration. This approach eliminates self-pacing, and is a less-biased, more accurate means to measure the degree to which fatigue limits activity. The Pittsburgh Fatigability Scale (PFS) is a validated, self-administered tool that measures both perceived physical and mental fatigability. Previous work with the PFS has focused on its relationship with physical activity and function. This symposium will extend our work by exploring genetic factors, prevalence, neurobiology and other novel relationships to identify at-risk populations and/or elucidate interventions that may reduce fatigability before further decline in activity and function lead to disablement. Specifically, Ms. LaSorda will present heritability and prevalence of physical fatigability in Long Life Family Study enrollees. Dr. Rosso will examine associations of brain grey matter volumes with physical and mental fatigability in LIFE Study participants. And, using data from MrOS, Ms. Renner will explore the relationship of physical and mental fatigability on prospective fall risk. We will also explore non-modifiable characteristics to further our understanding of prevention and predictive factors for those entering older age with very low thresholds to reach perceived higher fatigability. Namely, Dr. Simonsick will consider the link between emotional vitality and physical and mental fatigability in participants from the Baltimore Longitudinal Study of Aging. Dr. Schrack, the Discussant, will critically review the presentations and share future directions for fatigability research in older adults.