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Drug Shortage Impacts Patient Receipt of Induction Treatment

Objective Examine the impact of the 2011 shortage of the drug cytarabine on patient receipt and timeliness of induction treatment for Acute Myeloid Leukemia (AML). Study Design A retrospective cohort was utilized to examine odds of receipt of inpatient induction chemotherapy and time to first dose a...

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Bibliographic Details
Published in:Health services research 2018-12, Vol.53 (6), p.5078-5105
Main Authors: Hedlund, Nancy G., Isgor, Zeynep, Zwanziger, Jack, Rondelli, Damiano, Crawford, Stephanie Y., Hynes, Denise M., Powell, Lisa M.
Format: Article
Language:English
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Summary:Objective Examine the impact of the 2011 shortage of the drug cytarabine on patient receipt and timeliness of induction treatment for Acute Myeloid Leukemia (AML). Study Design A retrospective cohort was utilized to examine odds of receipt of inpatient induction chemotherapy and time to first dose across major (N = 105) and moderate (N = 316) shortage time periods as compared to a nonshortage baseline (N = 1,147). Data Collection/Extraction Methods De‐identified patient data from 2008 to 2011 Surveillance, Epidemiology, and End Results (SEER) were linked to 2007–2013 Medicare claims and 2007–2013 Hospital Characteristics. Principal Findings Compared to prior nonshortage time period, patients diagnosed during a major drug shortage were 47 percent less likely (p 
ISSN:0017-9124
1475-6773
DOI:10.1111/1475-6773.13028