Genomics and response to long-term oxygen therapy in chronic obstructive pulmonary disease

Chronic obstructive pulmonary disease (COPD) is a leading cause of death worldwide, and long-term oxygen therapy has been shown to reduce mortality in COPD patients with severe hypoxemia. However, the Long-term Oxygen Treatment Trial (LOTT), a large randomized trial, found no benefit of oxygen thera...

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Published in:Journal of molecular medicine (Berlin, Germany) Germany), 2018-12, Vol.96 (12), p.1375-1385
Main Authors: Seo, Minseok, Qiu, Weiliang, Bailey, William, Criner, Gerard J., Dransfield, Mark T., Fuhlbrigge, Anne L., Reilly, John J., Scholand, Mary Beth, Castaldi, Peter, Chase, Robert, Parker, Margaret, Saferali, Aabida, Yun, Jeong H., Crapo, James D., Cho, Michael H., Beaty, Terri H., Silverman, Edwin K., Hersh, Craig P.
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Arylsulfatase
Biomedical and Life Sciences
Biomedicine
Chronic obstructive pulmonary disease
DNA microarrays
Epithelial cells
Female
Gene Expression
Genomics
Human Genetics
Humans
Hypoxemia
Internal Medicine
Lung diseases
Male
Middle Aged
Mitochondria
Molecular Medicine
Obstructive lung disease
Original Article
Oxygen - therapeutic use
Oxygen enrichment
Oxygen therapy
Patients
Peripheral blood
Pulmonary Disease, Chronic Obstructive - genetics
Pulmonary Disease, Chronic Obstructive - therapy
Quantitative trait loci
Respiratory therapy
Single-nucleotide polymorphism
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Summary:Chronic obstructive pulmonary disease (COPD) is a leading cause of death worldwide, and long-term oxygen therapy has been shown to reduce mortality in COPD patients with severe hypoxemia. However, the Long-term Oxygen Treatment Trial (LOTT), a large randomized trial, found no benefit of oxygen therapy in COPD patients with moderate hypoxemia. We hypothesized that there may be differences in response to oxygen which depend on genotype or gene expression. In a genome-wide time-to-event analysis of the primary outcome of death or hospitalization in 331 subjects, 97 single nucleotide polymorphisms (SNPs) showed evidence of interaction with oxygen therapy at P  
ISSN:0946-2716
1432-1440
DOI:10.1007/s00109-018-1708-8