Anogenital Verrucous Carcinoma—A case report

• Published in: International journal of surgery case reports 2019-01, Vol.54, p.7-9
• Main Authors: Trøstrup, Hannah, Matzen, Steen H.
• Format: Article
• Language: English
• Subjects: Anogenital verrucous carcinoma; Case report; Squamous cell cancer variant
• ISSN: 2210-2612; 2210-2612
• DOI: 10.1016/j.ijscr.2018.11.017

•Verrucous carcinoma (VC) is a variant of squamous cell carcinoma.•Anogenital VC is a rare condition, which clinically presents as common genital warts.•Early recognition of VC and radical excision is crucial due to local destruction of tissue.•Recurrence of VC is not uncommon. Verrucous carcinoma is an uncommon variant of low-grade squamous cell malignancy with a low malignant potential but a high risk of recurrence. We report a case of a Human Papilloma Virus negative local verrucous carcinoma in the perianal area of a 45-year old otherwise healthy female. The tumor presented clinically as a persistent genital wart not responding to usual dermatologic local therapy. The patient was referred to the Department of Plastic Surgery and Breast Surgery after primary excision in a private practice setting of a general surgeon. Three months later, further excision revealed local lichen sclerosus inflammatory changes in close proximity to the excision scar. Due to the low occurrence of verrucous carcinoma in the perianal area, no guidelines are available for the management of this disease. Conflicting reports on the ethiology and the nomenclature and classifications of verrucous carcinomas exist. Avoid pitfalls in the diagnosis of a rare variant of squamous cell cancer with a high recurrence ratio: Common genital warts not responding to ordinary local antimitotic Podophyllotoxin treatment require biopsy to exclude verrucous carcinoma. Follow-up is recommended at a 3–6 months interval due to the relative high risk of relapse.